To "person 1": I wouldn't mix wellbutrin with MDMA (or similar drugs) because wellbutrin in known to lower your seizure threshold. Mixing it with MDMA would be much more likely to cause a seizure than MDMA alone, in an otherwise normal individual.
As for "person 2", the SSRI antidepressant will likely prevent them from rolling and may do so for a few weeks after discontinuing it. Trying MDMA isn't a good reason to stop taking an antidepressant. Also, if they're prone to depression, taking MDMA could potentially make that worse. Mixing it with adderall could cause additional stimulation and heart-rate increase, which could be dangerous.