Estrogenex is a nutritional supplement, available without a prescription, designed to normalize all hormone levels, yielding a wide spectrum of health and anti-aging benefits. Estrogenex is a multi-pathway formulation that minimizes or eliminates the undesirable effects associated with an estrogen dominant environment.
Hi Tech Pharmaceuticals put this out. Has anyone tried it? I don't think I like those cancer medication type AIs which are toxic.
Proprietary Blend – Chrysin, Green Tea Extract, Beta- Sitosterol, Muira Puama Root Extract, Quercitin, Soy ISO Flavones, Coumestrol Flavones, Dihydroxybergamottin Fruit and Naringen Fruit. This compound also contains Microcrystalline cellulose, Starch, Stearic Acid, Magnesium Stearate, Sodium Starch Glycolate, Triacetin, Silica, FD&C Red #3, and FD&C Yellow #6.
At high concentrations,
chrysin is reported to be an aromatase inhibitor in vitro. However, studies performed in vivo show that orally administered chrysin does not have clinical activity as an aromatase inhibitor
No evidence for the in vivo activity of aromatase-inhibiting flavonoids.
Saarinen N1, Joshi SC, Ahotupa M, Li X, Ammälä J, Mäkelä S, Santti R.
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Abstract
Measurements of the aromatase-inhibiting and antioxidative capacities of flavonoids in vitro showed that slight changes in flavonoid structure may result in marked changes in biological activity. Several flavonoids such as 7-hydroxyflavone and chrysin (5,7-dihydroxyflavone) were shown to inhibit the formation of 3H-17beta-estradiol from 3H-androstenedione (IC(50)<1.0 microM) in human choriocarcinoma JEG-3 cells and in human embryonic kidney cells HEK 293 transfected with human aromatase gene (Arom+HEK 293). Flavone and quercetin (3,3',4',5,7-pentahydroxyflavone) showed no inhibition (IC(50)>100 microM). None of the requirements for optimal antioxidative capacity (2,3-double bond with 4'-hydroxy group, 3-hydroxyl group, 5,7-dihydroxy structure and the orthodihydroxy structure in the B-ring) is relevant for the maximum inhibition of aromatase by flavonoids. After oral administration to immature rats at a dose of 50 mg/kg body weight, which considerably exceeds amounts found in daily human diets, neither aromatase-inhibiting nonestrogenic flavonoids, such as chrysin, nor estrogenic flavonoids, such as naringenin and apigenin, induced uterine growth or reduced estrogen- or androgen-induced uterine growth. The inability of flavonoids to inhibit aromatase and, consequently, uterine growth in short-term tests may be due to their relatively poor absorption and/or bioavailability.
http://www.ncbi.nlm.nih.gov/pubmed/11595503
β-sitosterol is being studied for its potential to reduce benign prostatic hyperplasia (BPH) and blood cholesterol levels. β-Sitosterol is also not recommended for individuals with sitosterolemia, a rare inherited fat storage disease. Because people with this condition have too much β-sitosterol and related fats in their system, taking β-sitosterol will only worsen this condition.
High levels of β-sitosterol concentrations in blood have been correlated with increased severity of heart disease in men having previously suffered from heart attacks
Dietary supplements for benign prostatic hyperplasia: an overview of systematic reviews.
Kim TH1, Lim HJ, Kim MS, Lee MS.
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Abstract
Benign prostatic hyperplasia (BPH) is a common chronic condition in older men. The aim of this overview of systematic reviews (SRs) is to summarise the current evidence on the efficacy and adverse effects of dietary supplements for treating BPH with lower urinary tract symptoms. We searched 5 electronic databases and relevant overviews without limitations on language or publication status. Six SRs of 195 articles were included in this overview. Serenoa repens was reviewed in 3 studies and no specific effect on BPH symptoms and urinary flow measures was observed. However, β-sitosterol, Pygeum africannum and Cernilton were reviewed in one study each, and significant improvement was observed for all three. All the included compounds have mild and infrequent adverse effects. SRs on β-sitosterol, Pygeum africannum and Cernilton have not been updated since 2000, thus an update of reviews on these compounds will be necessary in the future.
http://www.ncbi.nlm.nih.gov/pubmed/22883375
Muira Puama Root Extract: The root and bark are used for a variety of ailments by indigenous peoples in the Rio Negro area of South America, but the effectiveness of Muira Puama preparations are unproven. However, in a 1990 study conducted by Jacques Waynsberg at the Institute of Sexology in Paris, 62% of men who took muira puama extract noted an increase in sex drive and 51% of participants reported an increased ability to produce an erection..?
Quercetin has not been confirmed scientifically as a specific therapeutic for any condition nor approved by any regulatory agency. The European Food Safety Authority evaluated possible health claims associated with consumption of quercetin, finding that no cause-and-effect relationship has been established for any physiological effect
Soy-Isoflavones may affect human and animal health, although research is preliminary. Isoflavones such as genistein and daidzein, may affect the growth of estrogen-receptor positive and negative breast cancer cells in vitro. However, a 2010 meta-analysis of fifteen placebo-controlled studies said that "neither soy foods nor isoflavone supplements alter measures of bioavailable testosterone concentrations in men." Furthermore, isoflavone supplementation had no effect on sperm concentration, count or motility, and showed no changes in testicular or ejaculate volume, in one study. Studies using chemically pure isoflavones or plant materials with known concentrations of these compounds have indicated both positive and negative effects of isoflavones on disease progression and fertility.
Studies on mice indicate that isoflavones may cause thymic and immune system abnormalities and reduction in immune system activity
Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis.
Hamilton-Reeves JM1, Vazquez G, Duval SJ, Phipps WR, Kurzer MS, Messina MJ.
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Abstract
OBJECTIVE:
To determine whether isoflavones exert estrogen-like effects in men by lowering bioavailable T through evaluation of the effects of soy protein or isoflavone intake on T, sex hormone-binding globulin (SHBG), free T, and free androgen index (FAI) in men.
DESIGN:
PubMed and CAB Abstracts databases were searched through July 1, 2008, with use of controlled vocabulary specific to the databases, such as soy, isoflavones, genistein, phytoestrogens, red clover, androgen, testosterone, and SHBG. Peer-reviewed studies published in English were selected if [1] adult men consumed soy foods, isolated soy protein, or isoflavone extracts (from soy or red clover) and [2] circulating T, SHBG, free T, or calculated FAI was assessed. Data were extracted by two independent reviewers. Isoflavone exposure was abstracted directly from studies.
MAIN OUTCOME MEASURE(S):
Fifteen placebo-controlled treatment groups with baseline and ending measures were analyzed. In addition, 32 reports involving 36 treatment groups were assessed in simpler models to ascertain the results.
RESULT(S):
No significant effects of soy protein or isoflavone intake on T, SHBG, free T, or FAI were detected regardless of statistical model.
CONCLUSION(S):
The results of this meta-analysis suggest that neither soy foods nor isoflavone supplements alter measures of bioavailable T concentrations in men.
http://www.ncbi.nlm.nih.gov/pubmed/19524224
