Faladasgio
Greenlighter
- Joined
- Oct 24, 2018
- Messages
- 3
Would cannabis still get you high when on clozapine? I know it still affects me when on risperidone, dont know anything about clozapine though. Wondering if anyone has experience or knowledge
Effects of cannabis when on clozapine
- Thread starter Faladasgio
- Start date
You should, in all likelihood, still be able to get stoned.
Clozapine was the original "2nd-generation-antipsychotic", and it shares its mechanism of action - working mostly by blocking certain subtypes of serotonergic, adrenergic, histaminergic receptors - with other members of this class of drugs.
The main difference between clozapine and risperidone is that risperidone is also moderately effective at blocking dopamine receptors (which can cause it to have unpleasant side-effects at higher doses), while clozapine often achieves similar therapeutic efficacy despite showing relatively little activity as a dopamine antagonist.
The reason clozapine is prescribed less often than other antipsychotics is that in a minority of patients it can cause agranulocytosis, so you'd probably have to have your blood checked regularly, at least during the first months of treatment.
Clozapine was the original "2nd-generation-antipsychotic", and it shares its mechanism of action - working mostly by blocking certain subtypes of serotonergic, adrenergic, histaminergic receptors - with other members of this class of drugs.
The main difference between clozapine and risperidone is that risperidone is also moderately effective at blocking dopamine receptors (which can cause it to have unpleasant side-effects at higher doses), while clozapine often achieves similar therapeutic efficacy despite showing relatively little activity as a dopamine antagonist.
The reason clozapine is prescribed less often than other antipsychotics is that in a minority of patients it can cause agranulocytosis, so you'd probably have to have your blood checked regularly, at least during the first months of treatment.
