JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,465
Effect of cannabidiol on muscarinic neurotransmission in the pre-frontal cortex and hippocampus of the poly I:C rat model of schizophrenia.,Progress in Neuro-Psychopharmacology and Biological Psychiatry - X-MOL
Cognitive impairment is a core symptom of schizophrenia; however, current antipsychotic drugs have limited efficacy to treat these symptoms and can cause serious side-effects, highlighting a need for novel therapeutics. Cannabidiol (CBD) is a non-intoxicating phytocannabinoid that has...
One study claiming it "normalizes" it in rats.
THC seems to be know to elevate HR by 20 to 50 BPM.
I took a tricyclic anti-depressant before and my HR was INSANE on it (they're know mACh blockers).
Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer's disease?
Alzheimer's disease (AD) is a neurodegenerative disorder which accounts for 60–70% of the 50 million worldwide cases of dementia and is characterised …
Another study suggesting it limits acetylcholine activity.
Blocking acetylcholine seems to be associated with memory loss; some studies claim cannabis has cognitive benefits.
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Anyone comment from experience whether cannabis has significant effect on the mACh receptor (as other mACh drugs such as tricyclics, anti-psychotics and anti-histamines like promethazine do)?