S: MDMA, 6-APB, LSD/1P-LSD, DMXE, 2C-B, 4-HO-MET
A: Dexedrine, Psilocybin, Ketamine, ETH-LAD, 4-HO-MiPT, DiPT, TMA-2.
B: Adderall, Phenibut, 5-MeO-MiPT, Bromantane
B-: Vyvanse
C: DXM, Cannabis, Nitrous Oxide, Memantine, Ativan, Flualprazolam
C-: Kratom, Alcohol
D: Klonopin, Etizolam
E: Methylphenidate, Caffeine, Valium, Fascoracetam
F: Nicotine, Psuedophedrine
Z: Zopiclone, Benadryl
EDIT 05/2022: 6-APB added (S Tier). TMA-2 Added (A Tier.) Dexedrine moved from S -> A, Adderall A -> B, Vyvanse B-> B-. Alcohol upgraded from D -> C-.