It's really individual like someone said about if the antidepressants will dull the shrooms. I did shrooms while I was on Effexor XR and I definitely still tripped and felt the effects. Maybe the visuals weren't as intense but every other aspect of the trip was there, like the body high and mental and emotional high. Don't get me wrong I still had visuals but it was mainly colors enhancement, everything looked really bright and vibrant, my visual acuity became much more sharp and some CEV. But I didn't get the morphed, warped and swirling OEV. But the shrooms I had were regular Golden Teachers anyway which are moderate in potency. As for dosing start with half an eighth. But being that you take antidepressants you might want to try a full 8th just in case