This could be an age dependent thing here, if you are a younger user then it can entirely interact and you can have a bad time as in it can increase the risk of mania or a manic episode as well as hallucinations or other thoughts that might not be the norm,
Where as if you are older in life its less likely to have this effect combined providing you are using within what you are used to and not excessively
But yes SSRI's such as Sertraline and any other psychoactive medications can for sure have some kind of impact or effect when used in combination with cannabis