sekio
Bluelight Crew
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- Sep 14, 2009
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But even the wikipedia page suggests that clonazepam affects serotonin and acetylcholine. It does some things that most benzodiazepines don´t do.
If you read the reference, all the benzodiazepines tested reduce the release of ACh in a select part of a cat's brain... this is far from it effecting ACh in the muscles.
https://www.ncbi.nlm.nih.gov/pubmed/6133407The amount of released ACh was determined in 15-min samples by a bioassay on a segment from isolated guinea-pig ileum. It was found that benzodiazepines applied i.p. in doses of: 5 mg/kg (Diazepam), 10 mg/kg (Clonazepam) and 0.5 mg/kg (Flunitrazepam) decreased the ACh release in the effluent flowing out through the cannulated aqueduct.
This leads me to believe it's not an unique effect that clonazepam has, it's probably related to downstream effects from all benzos. I don't think it's a result of benzos binding to acetylcholine receptors either, or that would have been discovered in binding screens.