N&PD Moderators: Skorpio | thegreenhand
I enjoy the combo. Sober I cant really stand the feeling of DLPA, but when drinking some poppy tea, OMG I can eat a shitload of it.
Makes me feel pretty warm and gives me bellringers aka tinnitus.
This isn't an effect of increased opioid activity - this is due to the fact that Phenylalanine gets metabolized into L-Tyrosine, then from L-Tyrosine into L-DOPA, then gets deactylated into Dopamine then Dopamine Beta Hydroxylase converts it into Norepinephrine.
Phenethylamine is actually a more potent stimulant than Amphetamine
As a friendly reminder from this broken record, l-tyrosine is saturated under normal dietary conditions, so it follows that DLPA's psychoactivity should be roughly nil. Yes, there is auxiliary metabolism to phenethylamine, but that will get chopped to shit by MAO right-quick.
No, it's quite a bit less potent, even when potentiated via inhibition of mao. This is borne out by binding affinity data and anecdotal reports of recreational use.
ebola
One can't make assumptions upon the effectiveness of any opiate enhancer without prior experience from the test subject at least in terms of enhancement in using other substances.
Swamp Fox said:I don't appreciate the insults and I find it highly inappropriate.
Well that's funny because I recently read a study that claimed that PEA was vastly more potent in functional efficacy than Amphetamine.
But since you didn't read my post. . .
you wouldn't have realized that I said that the reason why it's effects are negligible is due to the fact that it's half-life is only 15 minutes at best.
I'll go back through my history to find it for you.
Not amused by your hostility, ebola. An admin, especially, should know better.
Phenylalanine is an amino acid, the "unnatural" form has been speculated to be an enkephalinase inhibitor, but IMO it is probably not active worth a damn at all in humans. If it is active, it's incredibly weak and has poor central bioavailibility.
D,L-phenylalanine is a mixture of 50% natural form (L-phenylalanine, found in protiens, used to make DOPA etc) and 50% unnatural form (D-phenylalanine, the speculated potentiator). As SwimmingDancer pointed out there is not a lot of precedence for D-phenylalanine being some sort of miracle potentiator...
The active "potentiator" in tonic water is quinine, but it's only presentas a flavouring, and you'd need to drink at least 2 litres of tonic water before you got a medicinal dose of quinine.
No.
Best of luck finding the relief you seek!
With that being said one of the most common opioid potentiator is Clonidine
I don't fully understand how this is supposed to be superior to L-Phenylalanine? Like it possibly slows the degredation of endogenous opioids?
That Wikipedia article is very poorly written and does not meet Wikipedia's criteria for proper sources. The 1989 article cited for the claim that there is a "possible blockage by D-phenylalanine of enkephalin (endorphin) degradation" does not in reality say that, all it says is that D-Phenylalanine was found to bind to carboxypeptidase A, in the same way that L-Phenylalanine does, only slightly stronger. The other relevant claims made in the article are completely unsourced.
I've tried L-Phenylalanine and I certainly did not find it to potentiate opioids at all, nor did I notice any pain relief. It's effects are pretty subtle, although unwanted side effects can be noticeable for certain people.
I don't fully understand what binding to caboxypeptidase A even does.
EDIT: There is an old thread in ADD about this, someone said that it probably doesn't do much and you'd have to take huge amounts of it, but that was just their educated opinion, not from personal experience.
EDIT 2: This article is better sourced than the Wikipedia article, and it does make D- And DL-Phenylalanine sound very promising. I might actually give D-Phenylalanine a try for pain (I have to say I don't honestly expect much though). Restoring the Natural Opioid System with D-Phenylalanine (DPA): A Novel Therapeutic Approach