which PCP derivative is the least stimulating and anxiogenic and most ketamine like.?
This is a smartass answer, but, ketamine?
I mean, obviously there will e considerable personal variability. Most arylcyclohexylamines will have stimulant properties, even ketamine is a stimulant of respiration/cardiac activity. It seems to me the 2'-keto ACHAs are more immobilizing than those with "plain" cyclohexane rings, but the truth is there are not a lot of human
in-vivo test data of ketamine/PCP analogs.
Logically if ketamine and MXE both can cause bladder damage in overuse then so can deschloroketamine, methoxyketamine, etc. But I don't think there are reported cases of PCP or its analogs causing bladder issues.
Changing the phenyl ring of PCP to a thiophene (TCP) or a benzothiophene (BTCP) causes greatly increased dopamine agonism/DAT transport affinity at the cost of reduced NMDA agonism.
Maybe you should track down the guy who "invented" MXE. I have a feeling he would have comparative SAR of the effects as I suspect he would have done a "screening program" to test several analogs of ketamine until arriving at MXE.
Also, not explored is the 4'-keto analogs of PCP...