I have used marijuana as an antidepressant which worked better than anything I ever tried. Unfortunately after completing a session about 5 years ago my body rejecting metabolizing the THC properly. This was a sudden reaction where any amount taken in either inhaled or as an edible would build up as if there was a reverse tolerance. I would get extremely high and the high would last for maybe 8-10 hours. This responce happened regardless of dose. At the end of the high I would be left with an incredible hangover that lasts sbout 30 hours. Experimenting with dose had the same effect even if I only did 1 milligram. The hangover is too much to deal with so I had to stop. I did ftom time to time return and test things out but the same thing happens every time regardless of dose. Recently I found a workaround using transdermal THC. THC transdermaly bypasses first pass metabolism so Im guessing that it doesnt convert to 11 hydroxy THC. Although THC is classified as psychoactive it's certainly not as psychoactive as 11 hydroxy THC. This method does work on my depression however at $10.00 a patch its way more expensive and definitely not as much fun. I originally thought that I was having a DDI with something else I was using but after cycling off the other meds I was taking the side effect stays. Im now thinking perhaps there is something wrong with glucuronidation as 11 hydroxy THC goes through glucuronidation before being converted to THC COOH and eventually eliminated from the body. It appears that THC itself is metabolized by CYP2C9 into the more psychoactive 11 hydroxy THC which I am now skipping by using transdermal delivery. Does anyone have any idea what might have happened or something I might try to remedy it.