Solipsis
Bluelight Crew
- Joined
- Mar 12, 2007
- Messages
- 15,509
While the more general title is what my core question revolves around, this is actually about a more specific case:
Someone I know (no really :D ) is a frequent drinker and has recently tried prescribed alprazolam for incidental use. Other options - even temporary - haven't been tried in the sedative department. There is some reliance / dependence on sedatives you could say.
This person wants to undergo treatment lasting a week of an antibiotic that is contraindicated with alcohol and inducers or inhibitors of CYP P450, not exactly sure if multiple subtypes or which.
Certainly CYP P450 enzymes metabolize MANY compounds, but not all drugs preoccupy the enzymes or induce / inhibit the same way. I assume that this would depend on dose amounts of the drug combined with how strongly / long they bind? So how exactly does one proceed to find out which drugs would be relatively harmless to ward off serious anxiety, etc without being significantly contraindicated?
Would you agree that that would be the sedative with the optimal ratio of efficacy of action vs. whatever determines CYP P450 taxing?
(P.S. There is also a prescription of an SSRI, seems strange cause that would also be a contraindication? Is her medical professional already pushing it, allowing little room left for say alprazolam use during the treatment with a week's duration?)
I am interested in both insight into such a situation, not actual medical advice mind you... as well as the general theory for furure reference.. Thanks!!
Someone I know (no really :D ) is a frequent drinker and has recently tried prescribed alprazolam for incidental use. Other options - even temporary - haven't been tried in the sedative department. There is some reliance / dependence on sedatives you could say.
This person wants to undergo treatment lasting a week of an antibiotic that is contraindicated with alcohol and inducers or inhibitors of CYP P450, not exactly sure if multiple subtypes or which.
Certainly CYP P450 enzymes metabolize MANY compounds, but not all drugs preoccupy the enzymes or induce / inhibit the same way. I assume that this would depend on dose amounts of the drug combined with how strongly / long they bind? So how exactly does one proceed to find out which drugs would be relatively harmless to ward off serious anxiety, etc without being significantly contraindicated?
Would you agree that that would be the sedative with the optimal ratio of efficacy of action vs. whatever determines CYP P450 taxing?
(P.S. There is also a prescription of an SSRI, seems strange cause that would also be a contraindication? Is her medical professional already pushing it, allowing little room left for say alprazolam use during the treatment with a week's duration?)
I am interested in both insight into such a situation, not actual medical advice mind you... as well as the general theory for furure reference.. Thanks!!