Chloride, sekio, why? For acylations and esterifications in general I, as long as there is no reason they would give inferior results, prefer acyl halides to acid anhydrides. They are clean, they don't require heating, and they do the job faster than tony blair runs when threatened with giving evidence under oath. And to add to their respective general superiority (IMO at least), if using bicarbonate as the base to scrub the HCl, then one can just watch for bubbling, and once it ceases, add a tiny bit more bicarbonate off the tip of a knife. If it continues to bubble off CO2, rxn is still going at it, add more base. If not, then you're golden.
The first, nasty response was NOT due to partial agonism/inverse or neutral antagonism. Cotton fever. Short lasting, terminated in response to a dose of tizanidine in solution, up the arse (oral seems to help little, but fast and strong response to tizanidine, have had cotton fever a handful of times, its fucking nasty ass, but plugging tizanidine has a VERY dramatic effect. Terminates it with extreme prejudice.)
Did another dose of dibenzoylmorphine, and fuckin HELL. There was a very, very small of dipropionylmorphine in there also, as I used the same beaker from a previous synthesis of prope dope, but merely a little bit on the bottom of the flask, it may have made me feel better for a few hours if withdrawing but thats IT.
But whilst it took a bit to kick in, I IV'ed the rest of the batch in one shot, mixed with the traces of prope from the other synths of the day. (or one of the others, rather. I can get to being a wee bit hyperactive in the lab when my autie hyperfocus turns everything tunnel-visioned and the lab and its kit/reagents is ALL I can see or think of, at least until I get desperate for a piss, or to go drop one, or its been too long since my last dose of opioid or chlormethiazole but thats about it, takes quite a lot to grab me and drag me away, kicking, screaming, swearing the air acidic and blaspheming fit to offend the devil his own good self
Its...err...its what I DO to relax, spend my spare time, if I'm not hiking in the woods to pick tasty wild fungal delicacies for my supper.)
And after about 20-30 seconds, onset quite slow, I didn't feel it even begin to take effect until maybe a half to a quarter ml was left in the syringe (5ml total), injecting quite slowly due to the use of a 30ga point, same happens using a 28ga but slightly faster onset. Feel the beginnings of that familiar, comforting warmth. But once it developed, did it EVER pack a rush. One of the most powerful I have ever experienced in my use of any opioid. Opioid history that I can remember includes the following:
Tramadol (hate it), codeine, dihydrocodeine, methadone, fentanyl, sufentanil, lofentanil, remifentanil and alfentanil, (of which alfentanil and lofentanil are the only ones I would bother doing again unless given to me for free), heroin (street gear, and...ahem...not street gear nor medically sourced, but I can vouch for its being absolutely and totally un-cut, and not in any way fucked with), opium (orally, rectally), kratom leaf and crystalline commercial alkaloid extract, damn potent however), dextropropoxyphene, meptazinol (selective MOR1 partial agonist), pod tea, opium alkaloid isolate, and the same reacted to a prope-dope opium edition, just whacked the whole lot of alkaloids in there with acyl halide after cleaning codeine out), oxycodone (meh) morphine sulfate, alpha-chloromorphide (WEIRD, strongly suspect mostly DOR agonism, my money on DOR1 due to mildish clonus in fingers, hands and feet, almost pure stimulant, although of a very different flavor to normal DARIs and releasers. Likewise fuck all in common with direct dopamine agonists [piribedil, alpha2 adrenoreceptor antagonism suppressed via clonidine, tizanidine], likewise sod all like betahistine, a histaminergic stimulantish nootropic) or AMPAkines, nor like pramipexole] Unique in my experience although a little similarity to aged kratom in some cases. Peculiar nature. A very odd duck.
Also dipropionylmorphine, dibenzoylmorphine. And out of all those, ONLY the dipropionylmorphine and the propionylated pantopon (opium isolate) can stand up to that rush I experienced last night. Jesus H.Bumfuck Christ. It lasted ages too. After shooting the mixed dibenzoylmorphine (90-95% of the total content) I NEEDED a cigarette, and not my e-fag either, something with harmine/harmaline in it, a bona fide cancer stick is what I wanted. Couldn't find much in my bag of baccy, damn I thought, out of cash because I blew it all on a new coolant pump for my condensers, didn't have quite enough for that actually either, but the guy in the pet store I have been on good terms with, (the less said to him about my calling animal protection on the store, twice, possibly three times actually, because they were keeping this poor, poor wee sugar-glider in a tiny aquarium-sized terrarium, with a few branches and synthetic leaves to hold on to, 3-3.5 feet long by maybe 1/3-1/4 tall and about 8 inch wide. I was furious, and I repeatedly called animal welfare in on the place, fish were overcrowded and the ill ones got fed, alive to piranha, which were overcrowded themselves and infighting like crazy)
They have cleaned up their act now, so I did spend money in there. I'd sworn never to do so again until, unless they cleaned their fucked up act. The guy I spoke to isn't a bad man, but some there must be. And he agreed to give me several pounds off the pump because I was some money short of the asking price, and could only have afforded a small, weak filter pump. Not good enough for my needs, and after explaining what I needed, and why, he got a better one for me. Gave my warm greetings to the resident feline, who ran up to me, not seen me for ages, wanting me to scratch his belly, rubbing up and purring and rolling all around me. Good to see the little ragamuffin. Missed the guy really.
Anyhow. Had no money for smokes, so went upstairs to see if there was anything up in my room. Nope. Went down again to the kitchen and back to work. Found a 3/4 of a rollup from earlier I'd left in the ashtray. And all the while, searching I was still rushing like I don't know what. When I got downstairs I was panting and had to support myself a bit on the sofa, and again in the kitchen. Swore and blasphemed several times in utter...I'm not quite sure. But the kind of thing when one has a mindblowing orgasm way beyond the usual realms of possibility, after being on a strong dose of a direct dopamine agonist, and it blows your head clean off type of thingy. Still going strong, barely able to compose myself whilst standing, indeed, it was some effort to keep on my own two feet.
Got my smoke and my hands were shaking, me thinking 'oh christ, oh fucking well bloodyfucked mother of god'. Absofuckinglutely nuts. Finished my most of a rollup, and went on to the e-fag, sat down heavily to go back to my videogame.
It should be noted I'd taken a couple of capsules of chlormethiazole (192mg per dose unit, two taken). And of note, do NOT do this in combination with chlormethiazole, I can do so because I am both highly tolerant to opioids, and whilst chlormethiazole has proved very benign for me in terms of tolerance, and lack of rebound if I do not take it, little to no withdrawal, although I am not, generally, abusing it or other downers. I do use recreationally intermittently if I choose to make some chlormethiazole, bromethiazole, or other downers of the GABAergic type, but not day in day out. As and when felt like, really. But this drug is barbiturate-esque, minus the AMPAr antagonism of the barbs. And if you fuck with it carelessly it will probably end you. I use it daily, 192mg 3x, to prevent seizures.
The shaking was nothing like myoclonus or seizure onset, rather, it was the effort of trying to contain myself in one, upright piece, the way one lies, shaking and panting like a dog after one long, hard utterly mental screw with a hot young, damned smart Kanner's chick. Flop off the sofa onto the floor kind of post-fucked-sideways type of shaking.
REALLY did not expect this. High continued for a few hours, 3 hours maybe 3 1/2 or a little more but not a great duration. When I smoked it got seriously, seriously intense. I don't quite know what was going on there.
I do have something to question, also.
After the synthesis. Not immediately, but after stripping the remaining acyl halide, and cleaning the salts out with methanol (from reaction of the acyl halide with the bicarbonate added as both HCl-sucker and indicator of rxn progress, due to cessation of CO2 evolution whence the reaction goes to completion, or at least, the acyl halide is consumed)
At first, lovely benzaldehyde-ish smell, not nearly so strong as benzaldehyde, nitrotoluenes or nitrobenzene. Fainter, sweeter, very pleasant, couldn't resist going back for another sniff several times haha. (mind you I was most certain that the halide was gone, so there was nothing noxious that could have injured me)
But after sitting for a few hours, an intense, intense odour of thymol, or specifically, of euthymol toothpaste. I do not see how thymol could be formed. I may have rextyl'd the morphine diester from propan-2-ol, I can't remember for sure, because I know I was very, very low on MeOH. Had to beg a vodka bottle's worth of isopropanol from someone because otherwise I'd have been stuck for the night and climbing the walls in frustration at not being able to do much in the lab. There would have been wailing and gnashing of teeth.
Questions are-one-what might that smell have been? I have never smelled either methyl or isopropyl benzoate. Nor benzoic anhydride, benzoin or benzyl alcohol. Nor many other compounds of this kind. It wasn't the acyl halide, which unlike propionyl chloride actually has a very pleasant odour behind the stinging sensation experienced due to the HCl from its hydrolysis. The smell took some time to develop, and whatever agent was behind it, was evidently somewhat volatile because it disappeared upon leaving the dibenzoylmorphine to stand. I could of course always make the methyl and isopropyl esters, but I really would prefer to be..well I wouldn't call it spoonfeeding since it's not my asking for help to produce anything, but just toss me a bone with this one, anyone smelled those esters before, it would save me from using valuable acyl halide, what very little methanol I have left until next payday, and any of the iPrOH, because I had to scav off someone and I don't have any to spare on something so trivial.
Summary-short high, not intense. But rush very prolonged and blew my bloody head off. Will try again as soon as I have a bit of morphine to spare. The rest of my script I can't use for that. It isn't morphine anymore.
Next on the ahem, as somebody called me, bourgeois junkie,'s tasting list-krokodil. Done clean, and done right. By somebody who takes pride in their art and their science. And that means no nasty ass harsh phosphorus/iodine-based reductions or anything even close
Wonder if desomorphine can one-up dibenzoylmorphine for that famed rush (of desomorphine-D)....
Shot up, and my god, my howling fucking crucified cunting christ on a unicycle shit FUCK!
Took a moment to take effect, slower than morphine, slightly faster than prope. But damn, shit on my fucking breakfast did it ever pack one HELL of a whallop. Not the high, which seemed short in comparison to prope or morphine. But the rush, bloody hell. I do not yet know if it was the combination with the dibenzoylmorphine (almost all of the total opioidergic material present) and traces of prope (which does pack an almighty rush when IV'ed) but this had a LONG rush, and it smacked me bleedin' well sideways.
NOT what I expected, not one tiny little bit what I thought was going to happen most likely.
Thanks for adding the forgotten caveat about dosage ranges. I am opioid-tolerant. That would not be a baseline start dose for an opioid naive human subject. I do not know what is, because A-I am not one. And B-I do not have one available who would suddenly decide to, or even find it acceptable to shoot up in the first place, and much less both something heroin-inspired and for that matter, that sod all is known about generally speaking.
Got about as much chance of that as somebody posting gold bars through my letterbox, or me winning a nobel fucking prize for service to clandestine chemistry haha.
(one must of course always keep striving
))
My typical morphine dose...varies. But I can shoot up to a gram and a half to a gram and three quarters if I can both source enough to do so, spare that quantity, and manage to dissolve it in an acceptable volume of water at an acceptable temperature. But more usually, I prefer to take my morphine in the guise of its dipropionyl ester, I.V and at a dosage of between 0.5g-750mg, 1g at most. Do not attempt this quantity. Not unless you are both highly tolerant, intimately familiar with the drug itself and preferably not with any depressants of the GABAergic type. I am both, and whilst I do take chlormethiazole alongside it, I am careful with the latter, and I am also used to it. I take the drug, as stated, for both prophylactic purposes and to actually stop a seizure in progress.
