Hi everyone,
For some background: I have post-concussion syndrome (a few years since the sporting accident). A nutritional GP is helping me with supplementation for the concussion. A recent SPECT scan showed significant hypoperfusion to my temporal lobes, and I was recommended to start dextroamphetamine to help improve my quality of life. Dextroamphetamine has been the only thing that I have found helpful out of everything I have tried. I am concerned about Neurotoxicity given the condition my brain is already in, and I am equally concerned about building up a tolerance to the dextroamphetamine. My issue is that my nutritional GP does not prescribe dextroamphetamine and is unfamiliar with neurotoxicity, tolerance, vitamin interactions, etc. I have been modifying my old regime to be more appropriate around the timing of the stimulant, as well as adding a few vitamins which seem to be quite beneficial (R-Alpha Lipoic Acid, L-Theanine, L-Arginine, Selenium, L-Tyrosine, Melatonin). This is what I have come up with:
6:15am
Banana
Thorne Basic B Complex
Vitamin B6 100 mg
Brain Active LongVida (Curcumin) 400mg
Vitamin D3 2000 IU
Treadmill
7:30 am
Acetyl-L-Carnitine 500 mg
R-Alpha Lipoic Acid 100 mg
Ubiquinol QH+ PQQ
L-Theanine 100 mg
L-Arginine 500 mg
8 am Breakfast
Dexamphetamine 3.33 mg slow release compounded from powder.
10 am
Acetyl-L-Carnitine 500 mg
N-Acetyl-Cysteine 600 mg
10:30 am
Apple
Pristiq 50mg
Lunch 12:00 pm
2:30pm
N-Acetyl-Cysteine 600 mg
Acetyl-L-Carnitine 500 mg
L-Theanine 100 mg
L-Arginine 500 mg
R-Alpha Lipoic Acid 100 mg
Dinner 6:30pm
Vitamin C 1500 mg
Mixed Tocotrienols and Vitamin E
Zinc Citrate 25 mg
Fish Oil (EPA 400 mg/DHA 200 mg) x 3
Magnesium Chelated 400 mg
Selenium 200 mcg
Fusion Probiotic (High Lactobacillus)
8pm
L-Tyrosine 500 mg
8:30pm
Topiramate 12.5 mg
9pm
Melatonin 3mg 6 hour time released
My questions are:
I think this is a great forum. I have found old posts incredibly useful. Thank you very much for any information.Dextroamphetamine Tolerance, Neurotoxicity, and General Advice
For some background: I have post-concussion syndrome (a few years since the sporting accident). A nutritional GP is helping me with supplementation for the concussion. A recent SPECT scan showed significant hypoperfusion to my temporal lobes, and I was recommended to start dextroamphetamine to help improve my quality of life. Dextroamphetamine has been the only thing that I have found helpful out of everything I have tried. I am concerned about Neurotoxicity given the condition my brain is already in, and I am equally concerned about building up a tolerance to the dextroamphetamine. My issue is that my nutritional GP does not prescribe dextroamphetamine and is unfamiliar with neurotoxicity, tolerance, vitamin interactions, etc. I have been modifying my old regime to be more appropriate around the timing of the stimulant, as well as adding a few vitamins which seem to be quite beneficial (R-Alpha Lipoic Acid, L-Theanine, L-Arginine, Selenium, L-Tyrosine, Melatonin). This is what I have come up with:
6:15am
Banana
Thorne Basic B Complex
Vitamin B6 100 mg
Brain Active LongVida (Curcumin) 400mg
Vitamin D3 2000 IU
Treadmill
7:30 am
Acetyl-L-Carnitine 500 mg
R-Alpha Lipoic Acid 100 mg
Ubiquinol QH+ PQQ
L-Theanine 100 mg
L-Arginine 500 mg
8 am Breakfast
Dexamphetamine 3.33 mg slow release compounded from powder.
10 am
Acetyl-L-Carnitine 500 mg
N-Acetyl-Cysteine 600 mg
10:30 am
Apple
Pristiq 50mg
Lunch 12:00 pm
2:30pm
N-Acetyl-Cysteine 600 mg
Acetyl-L-Carnitine 500 mg
L-Theanine 100 mg
L-Arginine 500 mg
R-Alpha Lipoic Acid 100 mg
Dinner 6:30pm
Vitamin C 1500 mg
Mixed Tocotrienols and Vitamin E
Zinc Citrate 25 mg
Fish Oil (EPA 400 mg/DHA 200 mg) x 3
Magnesium Chelated 400 mg
Selenium 200 mcg
Fusion Probiotic (High Lactobacillus)
8pm
L-Tyrosine 500 mg
8:30pm
Topiramate 12.5 mg
9pm
Melatonin 3mg 6 hour time released
My questions are:
- Is the timing of my vitamins appropriate around the dex? Could any of my timing interfere with it?
- Could any of my dinner time vitamins be moved to lunchtime without interfering with the dex? The ones I currently have with dinner are the ones I am concerned with, but I am taking too much with dinner.
- Is it safe to take L-Tyrosine and dex? I read a recommendation to only take it on dex off days, but I don't have any off days.
- Is there anything glaringly wrong with my L-Theanine or L-Arginine use? These I have not had cleared by the doctor.
- I think that the Dex loses potency after taking the Pristiq. Is this possible?
- I have not liked taking Melatonin. I have had very vivid dreams with it. I saw 5-htp is an alternative but this might interact with the Pristiq. Any ideas?
- The one side effect I have from the dex is increased migraine severity and frequency. My doctor put me on Topiramate for this, but I have found it very fatiguing. It has also made my memory issues worse. Does anybody know of an anti-migraine that would pair well with dex? My lead one at the moment is propanolol but this seems as though it would counteract the dex. Other options are lyrica and neurontin but I do not like their side effect profile.
- I read a study showing Adderall was better absorbed without food versus a fatty meal. I think I probably get a better result on an empty stomach also, but I find this hard to time around my mornings. Is it particularly detrimental to have dex with breakfast?
- During one month of taking dex, my tolerance has already built. There is a recommendation for taking off days during the week. My issue is that I am bed bound without it, but I still will probably end up taking weekends off. So many people support taking Memantine with dex. Would you recommend this?
I think this is a great forum. I have found old posts incredibly useful. Thank you very much for any information.Dextroamphetamine Tolerance, Neurotoxicity, and General Advice
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