I never have take an NRI but I have taken venlafaxine, never more than one antidepressant at time and I too have taken bupropion, escitalopram and praoxetine.
I expect that desvenlafaxine is going to be very similar to venlafaxine. How was your experience with that?
For that matter, what was your experience with each of those other antidepressants like? What were the positives and negative you can remember from each (venlafaxine included)?
I hope an time sustained antidepressant effect which leads me able to reduce Ritalin and too an anxiolytic effect which leads me able to kick off diazepam and sulpiride and pregabalin. But I know antidepressant effects are no suddenly such as Ritalin or Valium but an effect that lasts one or two months and is few noticeable. I only hope a better mood and anxiety relief
Okay...so it roughly sounds like you're using Ritalin and Valium (as well as the other sedative-hypnotics you mentioned) to try to stabilize your mood. Can you just go into a little more detail about the exact benefits you're getting from each of those?
When you say "I know antidepressant effects are no suddenly such as Ritalin or Valium", it sounds as though you're using them both to help with your depression.
On the other hand, saying you want to "reduce Ritalin and too an anxiolytic effect which leaves me able to kick off diazepam" makes me wonder if you might be using Valium & co mainly to offset anxiety caused by the Ritalin, which you're using for your depression (e.g. anhedonia, apathy, etc). Which did you start taking first, and what was your reason (i.e. main symptom) for starting each of those?
These two classes of meds have approximately opposite effects, and are often combined by users in an attempt to cancel out each other's side effects. This usually ends up gradually turning into a downward spiral, where you're essentially trying to pull of an increasingly tight balancing act between the two as your tolerance rises and withdrawal problems start to show up (sometimes within a couple hours, for high doses of benzos). IMHO it's an important thing to consider when thinking about what might help you in future.
In any case... I can't sincerely imagine that Ritalin + Valium would be particularly effective as a mood stabiliser, even in the short-medium term (and I don't remember reading any experiences by people claiming that it was). In terms of depression alone, I understand very much how Valium can feel like a very quick-acting and effective antidepressant (and, according to a few people, even a sustainable one - although sadly that wasn't the case for me, nor seemingly for the majority of people). The Ritalin...not so much - I personally react very badly to it, so I can't speak from experience, but I suspect (going by many of the reports I've read) that it'd be more likely to just risk turning straight depression/MDD into something closer to cyclothymia or bipolar 2.
What have you been diagnosed with? Does it include a mood disorder, and if so what type?
I think it's important to understand what exactly is pushing you to try stabilising your mood with the meds you listed, especially given that you don't seem to be prescribed a mood stabiliser (I suppose supiride could technically count as one, but to my understanding it's still more of a straight sedative than a proper mood stabiliser). Aside from depression, do you get episodes of mania, restlessness, severe anxiety (i.e. panic attacks and persistent ruminations, usually accompanied by insomnia), or any combination of those? Do they alternate, or occur at the same time? Do you every have periods (even if it's just hours or minutes) during which you don't have any of those symptoms?