What if I do want to take another suboxone after I smoked H will it not work or get me sick? I was told it only happens to put you in withdrawals when you take the subs to soon, in my case it’s different cause I took my last suboxone at 7am and just picked 7 grams. Will I not feel it?
Buprenorphine (the active compound in suboxone) is a high-affinity partial agonist.
This means it can bind to the opioid receptors much more tightly than heroin, but isn't good at activating them. At low doses, this makes it a relatively potent opioid because the better binding more than makes up for the inferior activation, but once you go beyond ~4mg, most of your receptors will already be occupied, so the high binding affinity is giving you diminished returns; there is consequently very little difference between an 8, 16 or 24 mg/day dose of bupe, because at that point you've effectively reached the "ceiling" of its opioid effect.
If you take suboxone while you're on heroin, the buprenorphine will displace the heroin from your receptors. Since a heroin addict is used to a *very* high level of opioid receptor activation, suddenly replacing it with bupe's half-assed receptor activation is effectively going to translate into withdrawal to them, made all the more painful by how sudden it is.
If you take heroin while you're on a high enough dose of suboxone, it is going to do fuck all, because it cannot displace the buprenorphine from your receptors. This is, in fact, a major advantage of buprenorphine in opioid maintenance therapy: Try as you might, you will not be able to get high on other opioids as long as enough bupe is in your system to keep the other opioids off your receptors.
People often seem to think that there is some sort of chemical reaction taking place if you take a partial antagonist (like buprenorphine) and an agonist (like heroin) at the same time that's responsible for precipitated withdrawal, but this isn't the case. It's simply that being forced down from a high level of opioid receptor activation (having heroin/oxycodone on your receptors) down to a moderate level (having your receptors occupied by buprenorphine) is going to feel like withdrawal. But if you're already at the moderate activation level from buprenorphine and you're shooting heroin, your activation level isn't going to change, because buprenorphine can displace heroin, but not the other way around; consequently, you are not going into precipitated withdrawal in this case, but you won't be getting high from the H either.