Solipsis dear you are incorrect. So long as you do not strap a mask on yourself or some other idiotic method, inhaling individual balloons poses almost ZERO risk of "hypoxia" you are fear mongering IMO with scary sounding words. The natural impulse to BREATH will FORCE a contraction of the diaphram when the brain determines it MUST have more oxygen. It is as difficult to cause brain damage from inhaling nitrous balloons as it is to cause it by deliberately holding your breath... in other words ALMOST IMPOSSIBLE.
And if you take B12 sublingual tabs before then after doing nitrous it will prevent completely any damage. The ONLY way to cause damage is to do truly staggering amounts, as in an entire large dentist's cylinder of it in the space of a few hours. And no one doing whippets is going to end up consuming that much... problems from nitrous are just about THE RAREST of all drug injuries, as in literally only a few documented cases in the entire literature, ever.
Still I have had the experience myself of getting very blue lips and feeling like utter shit. And I wasn't using insane amounts, it was what I would call what to expect in a party setting. I assure you the blue was not painted on. Don't be so quick to say that everything is cool and just relax.
I do recommend that people blow into their balloons before starting to inhale. Also, when you are far gone on nitrous apparently some people can get sort of apneu and stop breathing for a bit. Not like suffocating of course but still combined with inhaling pure nitrous it can be enough to get hypoxic. I will say it again it really sucks ass and it can get you bummed out for maybe 20-30 minutes. I don't know how much real damage it does, I just hope people can prevent getting the same feeling I did is all. And I know of others who have had this as well.
Also I proclaimed some worry about nitrous thinking about combinations, something not taken into account when reading back literature on the general safety in a medical setting with mixed-in oxygen.
I myself have gotten something like an epileptic fit or seizure on LSD + N2O (as I understand it you shouldn't be too quick calling something a seizure so I am not sure), anyway I went stiff as a board and I felt like shortcircuiting hardcore. I was scared for my physical well-being, not ego-wise but just feeling terribly unhealthy and alarmed by what my body was telling me. After that I went very easy on the combo but still got similar things only milder.
Not sure what happens to your seizure threshold with similar combinations but it turned me off.
On a whole other occasion a friend of mine got really fucked on nitrous while on 2C-I and K, he lost his feeling of hot and cold and was very stuck mentally. Of course that doesn't say a lot about the physical safety of nitrous but it should be mentioned because it is still something you do not want. I was 10 seconds away from calling the paramedics on the guy. It was that bad.
Nitrous in general might not pose too big of a risk in terms of lasting harmful effects but still even when I supplemented with vitamins including B when I did more than a couple
sometimes I could just feel like I was missing a lot of nutrients - huge fatigue and feeling cold inside. You are more than welcome to explain all of this to me.
Honestly I don't care how safe you are feeling about nitrous, but personal experience tells me to watch my ass especially with combinations. I am very happy for you if you have never gotten negative effects with it but that doesn't mean that it isn't possible.
Be sensible, not cocky.