Limpet_Chicken
Bluelighter
- Joined
- Oct 13, 2005
- Messages
- 6,323
Now, an off the cuff remark in my recent thread about halomorphides, concerning the stereochemistry of them and derivatives, got me thinking. The dextro-isomers are often NMDA antagonists, whilst the laevo- are the opioids. I could easily get hold of PCl5, PCl3 or sulfuryl chloride to attempt stereochemical inversion.
Also, does potency as NMDA antagonist of the D-isomer of the phenanthrene opioids correlate at all with potency as a MOR agonist of the corresponding L-isomer? that is to say, do the more potent opioids in the family result in more potent NMDA antagonists? just curious really. But it would be interesting enough to sample the D-isomers of any of the common, or less common ones anyway regardless.
Also, does potency as NMDA antagonist of the D-isomer of the phenanthrene opioids correlate at all with potency as a MOR agonist of the corresponding L-isomer? that is to say, do the more potent opioids in the family result in more potent NMDA antagonists? just curious really. But it would be interesting enough to sample the D-isomers of any of the common, or less common ones anyway regardless.