Harm Reduction Could Chlorpheniramine (an CYP2DA inhibitor) ruin a Codeine or Hydrocodone high?

[supersonic89]

Hey buddies,

The last week I was quite congested (it is winter where I live) and I was taking some chlorpheniramine. I know that chlorpheniramine is almost a kind of SSRI and apparently it is an inhibitor of the CY2PDA enzyme. The same that most opioids use to metabolize into more potent metabolites.

I was planning to take some Codeine today but am I afraid that this chlorpheniramine crap will inhibit the metabolization of Codeine? I'm right? Or low doses are not very worrisome (2 mg x 6 days) and I know this stuff has a long ass half-life.

 

[negrogesic]

The antihistamines are generally weak inhibitors there shouldn't be an issue. Promethazine inhibits CYP2D6 and it seems to behave well with codeine.

 

[supersonic89]

The antihistamines are generally weak inhibitors there shouldn't be an issue. Promethazine inhibits CYP2D6 and it seems to behave well with codeine.

Ok thank you very much @negrogesic you are a person with extensive knowledge so I totally believe you.

One last question, if I want to mix the Codeine with tramadol should I take the Codeine first or the tramadol? Maybe the tramadol first until it metabolize into odsmt?

 

[HOOH]

Codeine and tramadol are metabolized by the same enzyme so it doesn't really make a big difference.

 

[supersonic89]

Codeine and tramadol are metabolized by the same enzyme so it doesn't really make a big difference.

So taking both would there be no problem? Or would it cause a kind of saturation of the drugs in the enzyme that metabolizes them?

 

[HOOH]

So taking both would there be no problem? Or would it cause a kind of saturation of the drugs in the enzyme that metabolizes them?

Well it wouldn't be a problem insofar as it doesn't matter in which order you take them, and yes, there is a sort of "cap" at how powerful these drugs can be as they first need to be metabolized before they are active compounds