Soulfake
Bluelighter
- Joined
- Aug 12, 2010
- Messages
- 160
I have a few questions about the conversion of (for example) an HCL-salt form of a chemical into the free base and/or converting the base further into another salt like citrate, ascorbate, acetate etc.
I also have some problems understanding the chemical properties of amino acids which are zwitterion/dipolar ions and I haven´t found articles that explain how those dipolar amino acids react with bases/acids. For example Arginine which has a ph of 10,5-12 as the free base and a ph of ~6 as the common HCL salt, would Arginine with it´s basic nature yield a "arginate salt" if mixed with a acidic substance like Phenibut which has a ph of 2,5?
What does the ph-value tell about the probably best salt form for the substance? For example Phenibut with it´s very sour PH of 2,5 would give quite different dissociation rates etc. if either made into an basic salt like arginate (or wouldn´t it be basic/would the low ph of Pheni and the high ph of Arginine cancel each other out to some degree?) or citrate? (the citrate form is used as "Citrocard" in russia, a paper states that the citrate is quite better than the hcl).
What about "semi-neutral" substances like Caffeine with a ph of 6-8? If anyone has general informations about the difference and properties of salts I would be thankful. I know that there are some drugs sold as a lysine-salt like Ibuprofen-lysinate, can you use any amino acid to produce a salt?
How can there be salts of a substance and also be salts with the substance? For example Lysine HCL and Ibuprofen lysinate? Is this because of the dipolar properties of Lysine?
If anyone knows an article that explains how exactly the negative and positive pole of the molecule reacts with bases/acids and how the binding with those would look like as a picture of the molecule/salt please let me know.
If I want to convert a HCL salt of a substance into the free base I can simply add Sodium Bicarbonate in the right amount, the only problem with this is the NaCl byproduct which would be problematic if one needs a certain amount of the chemical or uses it often. Is there a different technique to convert something into a base which doesn´t involve special lab equipment or hardly obtainable substances? I guess the procedure with a stronger base than Sodium Bicarbonate would need more precision and safety measurements, testing of the final ph-value etc.?
If I have the free base I can simply convert it for example into the citrate or ascorbate salt by simply adding adequate amounts of ascorbic or citric acid? Does this work with other acids like Acetic acid too?
It´s not possible to convert an HCL salt into a different salt directly/without converting it into a base in between, right?
And my last question would be what happens if I mix e.g. Phenibut with Citric Acid in water, then adding some Bicarbonate? Would this work too?
I hope this questions are allowed but as it´s just converting the salt-form of substances and not substances themselves I guess it´s ok.
I also have some problems understanding the chemical properties of amino acids which are zwitterion/dipolar ions and I haven´t found articles that explain how those dipolar amino acids react with bases/acids. For example Arginine which has a ph of 10,5-12 as the free base and a ph of ~6 as the common HCL salt, would Arginine with it´s basic nature yield a "arginate salt" if mixed with a acidic substance like Phenibut which has a ph of 2,5?
What does the ph-value tell about the probably best salt form for the substance? For example Phenibut with it´s very sour PH of 2,5 would give quite different dissociation rates etc. if either made into an basic salt like arginate (or wouldn´t it be basic/would the low ph of Pheni and the high ph of Arginine cancel each other out to some degree?) or citrate? (the citrate form is used as "Citrocard" in russia, a paper states that the citrate is quite better than the hcl).
What about "semi-neutral" substances like Caffeine with a ph of 6-8? If anyone has general informations about the difference and properties of salts I would be thankful. I know that there are some drugs sold as a lysine-salt like Ibuprofen-lysinate, can you use any amino acid to produce a salt?
How can there be salts of a substance and also be salts with the substance? For example Lysine HCL and Ibuprofen lysinate? Is this because of the dipolar properties of Lysine?
If anyone knows an article that explains how exactly the negative and positive pole of the molecule reacts with bases/acids and how the binding with those would look like as a picture of the molecule/salt please let me know.
If I want to convert a HCL salt of a substance into the free base I can simply add Sodium Bicarbonate in the right amount, the only problem with this is the NaCl byproduct which would be problematic if one needs a certain amount of the chemical or uses it often. Is there a different technique to convert something into a base which doesn´t involve special lab equipment or hardly obtainable substances? I guess the procedure with a stronger base than Sodium Bicarbonate would need more precision and safety measurements, testing of the final ph-value etc.?
If I have the free base I can simply convert it for example into the citrate or ascorbate salt by simply adding adequate amounts of ascorbic or citric acid? Does this work with other acids like Acetic acid too?
It´s not possible to convert an HCL salt into a different salt directly/without converting it into a base in between, right?
And my last question would be what happens if I mix e.g. Phenibut with Citric Acid in water, then adding some Bicarbonate? Would this work too?
I hope this questions are allowed but as it´s just converting the salt-form of substances and not substances themselves I guess it´s ok.
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