I dont care how old this post is... and I dont care what these people saying it is a placebo effect think say or feel... they are WRONG... I didnt think there was a difference until I one day I took 5, 7.5/500 M358 mally hydrocodones, and barely felt anything, and then the next day I took 2, count them 2 watson 385 hydrocodone, 7.5/500, and I got the most incredible, great feeling high, how can you call the a placebo effect, i didnt get high at all off 5 of the mallys, and the next day i got high as hell, euphoric and everything off 2 watsons, and if anything, my tolerance would have gone up from the 5 mallys, not down, it was like 14 hours later that I took the watsons, it is not placebo, anyone who says it is must be opiate newbs, because people that have no tolerance at all, or close to no tolerance, will get high off any brand, ive been taking opiates for years, hydros, oxys, methadone, fentanyl, and 2 of the watsons got me high as a bastard, same with watson 749 percs, 5/325, 3 of them got me higher than 8 mally 5/325, and now I bid you adue, never to login again, bye bye junkies, and non junkies (who think brand doesnt matter)