I'm not sure. I started taking 2 10 mg lortab pills on Friday nights. That led to 3 or 4 pills spread out over hours. I'd be high all Friday night through the first half of Saturday. I did that for several weeks with no opiate use during the week. I just started feeling sick at work on Tuesday afternoons. That was the first time I had felt sick from opiates, so I didn't recognize what it was at first.
I've been through opiate withdrawal lots of times since then. There isn't a delay anymore. If I start taking them, I feel withdrawal pretty much as soon as the drug wears off.