Opioids Coffee opioid antagonism??

[Aqlis]

I remember reading something... somewhere (very informative, I know) recently about coffee containing some alkaloid(?) with opioid antagonist properties. can anyone comment and elaborate/dispel this notion? thanks

 

[Keif' Richards]

That would be really surprising to me. I think that if there is an alkaloid contained in coffee that antagonizes Opioid receptors, than it is found in levels below what would be needed to produce clinically significant effects. There are too many people out there drinking coffee daily for society not to make the connection after all of this time. There are a lot of things that fly under the radar for long periods of time, but there are so many people out there consuming coffee and taking Opioids. All of these people must go the occasional morning without drinking coffee to notice.

That's my opinion. There could be something in coffee that antagonizes Opioid receptors, but not enough of it to make it relevant to a person using Opioids.

 

[plumbus-nine]

Caffeine is bad during opioid withdrawal, maybe it was referring to this, but its due to caffeine's adenosine antagonism which basically blocks the brain's tiredness signal molecule.

 

[negrogesic]

Caffeine might exacerbate withdrawal symptoms but it isn't an opioid antagonist

However it looks coffee maybe have antagonistic effects, particularly when roasted:

4-Caffeoyl-1,5-quinide in roasted coffee inhibits [3H]naloxone binding and reverses anti-nociceptive effects of morphine in mice - PubMed

These results suggest that the previously reported anti-opioid activity of instant coffee is caused primarily by the presence of 4-CQL, and to lesser extent by other cinnamoyl-1,5-quinides.

pubmed.ncbi.nlm.nih.gov

I imagine when they make instant coffee they roast the fuck out of it.

 

[paranoid android]

Ya i love having morphine with my morning coffee ive never had a problem

 

[G_Chem]

Caffeine might exacerbate withdrawal symptoms but it isn't an opioid antagonist

However it looks coffee maybe have antagonistic effects, particularly when roasted:

4-Caffeoyl-1,5-quinide in roasted coffee inhibits [3H]naloxone binding and reverses anti-nociceptive effects of morphine in mice - PubMed

These results suggest that the previously reported anti-opioid activity of instant coffee is caused primarily by the presence of 4-CQL, and to lesser extent by other cinnamoyl-1,5-quinides.

pubmed.ncbi.nlm.nih.gov

I imagine when they make instant coffee they roast the fuck out of it.

This may be why I only like white bean or very light roasts.

-GC

 

[Joey]

I remember reading something... somewhere (very informative, I know) recently about coffee containing some alkaloid(?) with opioid antagonist properties. can anyone comment and elaborate/dispel this notion? thanks

If there's a property there it's very very mild on some set of receptors which will not wreck anything about your high or reduce your chance of an od