Cocaine 10 hours after tramadol

[Mrsolidzx]

Taken 50mg tram 9am then 50mg 12am. Can i have a few bumps and i mean only a few bumps of cocaine about 10pm?? As in will it it have an negative consequences, will they interact, will i die etc.Thanks

 

[raphaelvize]

I wouldn't if I were you because of the risk of serotonin syndrome since both tramadol and coke increase serotonin. Also tramadol lowers the seizure threshold so you would be more at risk of getting a seizure with the cocaine.

To be safe, my advice is wait at least 24 hours before having any coke.

 

[Rexeh]

2 x 50 mg Tramadol and then waiting for at least 12 hours before doing some bumps of Cocaine shouldn't be too much of a problem so go ahead and try it oit is my humble opinion...


-- Peace o/

 

[Rexeh]

Cocaine blocks the re-uptake of dopamine, norepinephrine, and serotonin. This causes a buildup of these neurotransmitters, as they remain in the synapse after the nerve impulse and continue to activate the receptors. The primary effects felt are from dopamine (pleasure) and norepinephrine (stimulation), although this is obviously an over-simplified description.



-psilo-

Toxicity resulting from excessive intra-synaptic serotonin, historically referred to as serotonin syndrome, is now understood to be an intra-synaptic serotonin concentration-related phenomenon. Recent research more clearly delineates serotonin toxicity as a discreet toxidrome characterized by clonus, hyper-reflexia, hyperthermia and agitation. Serotonergic side-effects occur with serotonergic drugs, and overdoses of serotonin re-uptake inhibitors (SRIs) frequently produce marked serotonergic side-effects, and in 15% of cases, moderate serotonergic toxicity, but not to a severe degree, which produces hyperthermia and risk of death. It is only combinations of serotonergic drugs acting by different mechanisms that are capable of raising intra-synaptic serotonin to a level that is life threatening. The combination that most commonly does this is a monoamine oxidase inhibitor (MAOI) drug combined with any SRI. There are a number of lesser-known drugs that are MAOIs, such as linezolid and moclobemide; and some opioid analgesics have serotonergic activity. These properties when combined can precipitate life threatening serotonin toxicity. Possibly preventable deaths are still occurring. Knowledge of the properties of these drugs will therefore help to ensure that problems can be avoided in most clinical situations, and treated appropriately (with 5-HT(2A) antagonists for severe cases) if they occur. The phenylpiperidine series opioids, pethidine (meperidine), tramadol, methadone and dextromethorphan and propoxyphene, appear to be weak serotonin re-uptake inhibitors and have all been involved in serotonin toxicity reactions with MAOIs (including some fatalities). Morphine, codeine, oxycodone and buprenorphine are known not to be SRIs, and do not precipitate serotonin toxicity with MAOIs.

Hope those two tidbits about both Cocaine and Tramadol helps, IIRC Tramadol is an SNRI whereas Cocaine is mostly a DARI IIRC, please someone correct me if I'm wrong :/ (source: http://www.erowid.org/).


-- Peace o/

 

[Mrsolidzx]

Thanka for response but any chance u can dumb that down haha??

 

[Keif' Richards]

Nobody can tell you if you'll be one of the unlucky few to suffer an immediate fatal reaction to the combination of Cocaine and Tramadol. It's unlikely my friend, but in the grand scheme of drug use, you would be better off to save the Cocaine for another time, but it's unlikely that you will experience catastrophe. In short, both Cocaine and Tramadol have separate properties that lend themselves to negative reactions.

It's a calculated risk, but I think you should get some practice in making some responsible decisions for yourself. We tend to make concessions to our desires in a step-wise manner. You can end up taking larger risks than what you might have originally intended.