I find Benadryl, or really preferably sleepinal capsules (diphenhydramine HCL powder, in 25 and 50mg capsules) to be a decent opioid/bupe potentiator... for sure! But I do not like that shit when taking amp.. I have like 5 scripts of clonidine just sitting in my drawer at home.. have never really thought of it as something to help comedowns or anything, just figured it was some weak med to help make my klonopin a bit more effective, which are already very effective and my doctor did mention it helped with sleep, but she was also giving me the clonidine in hopes I would go down on my klonopin daily dosage.. I didn't know it worked as a good sleep aid or helped out with stimulant comedowns like that, I thought it would just be something super subtle, typical non-narcotic, worthless drug honestly, I don't know why, just did... so I never bothered filling them..
But, now that I have read this, I am going to go fill one of my scripts and see how it goes, wont over do it with them of course.. but I have wicked bad insomnia and just general sleeping issues and even with klonopin(3-4mg sometimes 5mg a day), and sleepinal or sometimes melatonin along with my normal 8mg of bupe a day (2mg of 'tex IV 4x a day), and most of the time some good herb too... I am still waking up in the middle of the night, unable to go back to sleep, unless I pop an extra kpin... it sucks.. especially when I have to wake up early for work the next day, and get like 3 hours of sleep.. very glad I read this thread, it was very informative.. for some reason I always thought clonidine was going to be useless.. but apparently I was wrong! Shit.. I am still learning about drugs, and have done just about everything under the sun.. but not clonidine yet. Will try them, and see what happens!