Dys0rdeR
Greenlighter
- Joined
- Apr 5, 2011
- Messages
- 17
Hi all. So today I just had 3 perc 10/325's left and wanted to make the most out of them, so I consulted several opiate potentiation threads and decided on a strategy that seemed viable. Here is what I did:
T-45: 600 mg cimetidine consumed
T-35: 40 mg DXM, 25 mg diphenhydramine and 330 mg naproxen consumed
T-20: 2 tums ultra strength 1000 consumed
T-0: ate my 3 perc 10's
I let 40 minutes go by and am not feeling at all what I was expecting. Normally 30 mg oxy gets me decent within half an hour give or take a few minutes. Nothing special, but I normally feel nice. I go downstairs and eat damn near 2/3 a jar of peanut butter (for the potentiating effects of the fat). I start to search for answers on my phone and come across a thread where someone is saying that taking cimetidine to potentiate oxy is not exactly what I thought it was. According to what I read, and correct me if I'm wrong, is that cimetidine also inhibits the CYP2D6 liver enzyme, which is apparently needed to metabolize the oxy into oxymorphone (what we ultimately want). Also it seems like from what I've read that with all of this liver enzyme blocking, it will will cause the opiates to not break down and metabolize as qucikly. Meaning the duration of the high should last longer due to staying in your system longer, but on the same token, could that also cause the dose to take longer to peak? It's finally starting to feel like it's kicking in now as I finish typing this and it's been 2 hours since I took the percs. I'm getting that lovely warm, fuzzy and itchy feeling now.
So in other words my question is can cimetidine cause the onset of an oxy dose to take longer to kick in? I will keep ya'll posted to report how it continues to go. In the meantime, I'd love it if someone could shed some light on this for me.
Thanks,
- Dys0rdeR
T-45: 600 mg cimetidine consumed
T-35: 40 mg DXM, 25 mg diphenhydramine and 330 mg naproxen consumed
T-20: 2 tums ultra strength 1000 consumed
T-0: ate my 3 perc 10's
I let 40 minutes go by and am not feeling at all what I was expecting. Normally 30 mg oxy gets me decent within half an hour give or take a few minutes. Nothing special, but I normally feel nice. I go downstairs and eat damn near 2/3 a jar of peanut butter (for the potentiating effects of the fat). I start to search for answers on my phone and come across a thread where someone is saying that taking cimetidine to potentiate oxy is not exactly what I thought it was. According to what I read, and correct me if I'm wrong, is that cimetidine also inhibits the CYP2D6 liver enzyme, which is apparently needed to metabolize the oxy into oxymorphone (what we ultimately want). Also it seems like from what I've read that with all of this liver enzyme blocking, it will will cause the opiates to not break down and metabolize as qucikly. Meaning the duration of the high should last longer due to staying in your system longer, but on the same token, could that also cause the dose to take longer to peak? It's finally starting to feel like it's kicking in now as I finish typing this and it's been 2 hours since I took the percs. I'm getting that lovely warm, fuzzy and itchy feeling now.
So in other words my question is can cimetidine cause the onset of an oxy dose to take longer to kick in? I will keep ya'll posted to report how it continues to go. In the meantime, I'd love it if someone could shed some light on this for me.
Thanks,
- Dys0rdeR