Benzos Chloral Hydrate and dosage

[megawoof]

does anybody have experience of this substance?
i have ordered a bottle which should arrive in next few days
i have searched the net about dosage and when its made up in chemist 5ml teaspoon contains 500mg
would be good to here of anybodies experience with this substance

 

[DoctorChemX]

Chloral hydrate is almost 200 years old, it was one of
the first substances ever discovered. Bare in mind it
is metabolized by the body into trichloroethanol, which
seems to be about 100x as potent as normal ethanol.

I'd be curious to know the effects though, as i too have
not really heard about many experiences, i do know they
still use it to sedate CHILDREN at some childrens hospitals
however, but only when they monitor them for breathing,
as chloral hydrate is an extremely safe sedative, except for
the fact that it can cause sudden respiratory failure in about 1 in
15 thousand people, kinda like chloroform, so be careful.

As for effects, i'm pretty sure it's one of the most potent
sedatives known, it's used quite widely in veterinary medicine
as a large animal sedative, the csiro use it to sedate kangaroo's
with darts. It's also used as a horse tranquilizer and veterinary
anesthetic, so it's extremely potent, it will knock an average
sized human out completely, and either put them to sleep or
put them in a state of complete anxiety-free calm, but as far
as euphoria is concerned, i've never heard reports of that as such.

- Peace -
DrChem

 

[megawoof]

thanks for your reply
in the united kingdom choral hydrate isnt listed as a controlled substance even though to get at chemist you need a private prescription i have ordered it online from vet web site so wont come in syrup form probably white crystals its says 500g bottle just nervous about dosage suppose i will have to be very careful

 

[DoctorChemX]

thanks for your reply
in the united kingdom choral hydrate isnt listed as a controlled substance even though to get at chemist you need a private prescription i have ordered it online from vet web site so wont come in syrup form probably white crystals its says 500g bottle just nervous about dosage suppose i will have to be very careful

Always start with a very small dosage(50mg preferably) from memory chloral
hydrate is taken in about 100mg doses on average but i could be wrong there
so definitely check it up. Also please make sure you have a friend with you when
you dose, in case you react adversely to it. Other than that, enjoy! And tell us.

 

[Fire&Water]

"Dill Pickles" - havent seen em' in 25 years, start low, I remember the heavy (real) downer effect...

 

[Alex000]

Wow, Chloral, well definitely report back. Not jusre on dosing.

 

[rhizome]

My wife was prescribed CH as a sleep aid for a while- pretty sure they were 100mg spansules, but please don't base your dose on that.

Umm... ate one, 15 minutes later basically fell forward dead asleep, woke up groggy as hell 14 hours later. That's about the whole TR.

Nothing recreational about this one.

 

[doppelganga196]

^ This exactly. Doctors use it as a last last last resort for severe insomnia, like after z drugs, benzos, barbiturates etc dont work.

*edit* Come to think of it i wouldnt mind experimenting with this some day, just as long as i dosed in bed.

 

[Wesley_pipes_27]

Add a tiny bit to your favorite alcoholic drink and you have the mythical "Mickey Finn." Be Careful though !!

 

[AlphaOdure]

Any updates? have some stock... thinking about trying!!! I have a whole 50mg

 

[xxxyyy]

i've no firsthand experience with this, but chloral hydrate is available as an hypnotic in strengths of 500mgs and 250mgs in germany and switzerland. so i just going on that i'd say the dosage suggestion of 50-100mgs seems low, but better play it safe i suppose, especially with something that's known to cause respitory depression.

 

[QUARE]

All those chloride on such a simple molecule arent toxic ?

 

[AlphaOdure]

that was a typo, i meant 50g. actually. And QUARE.. just b/c there is a chloride atom in the molecule; doesn't mean its that same as chloride itself. The key to a substance being toxic is its reactivity in the human body, of which CH is not. However there is a metabolite of CH that's though (although no known beyond a doubt) that has high reactivity. No matter, even this metabolite... if its active in high enough amounts AND has the reactivity levels hypothesized (but again never proven) its still not nearly as toxic as ethanol.

Anyway, given how much i have, im going to test around 50mg to 100g before trying therapeutic doses.

 

[Shadowsblaze]

We had a bar down here that was closed because of drug problems one of them being that the barmaids and bartenders were dosing people with chloral hydrate. People that they didn't want in the bar they would add it too there drinks with those little straws, and it resulted in people falling asleep and then simply taken outside. They were robbed and some were beaten. I had a buddy they pulled it on and he was pissed and decided to return out of spite. He said he used a plant down here that contained atropine and when they dosed him he simply ate more and said he had one hell of a buzz by the end of the night. He eventually stopped going though because these people were bad news and he didn't want to push his luck. Someone told me it was open again but under a different name, not that I care it wasn't my kind of bar.

 

[QUARE]

I have no doubt that ethanol is toxic, but when I look at this molecule it looks to me like industrial chemical rather than a drug. I know its classified harmful in some country and this is the main reason why it is not used anymore, it has been replaced by Barbiturate which was also too dangerous because of the low LD50 and then replaced for Benzodiazepines which are pretty safe.

Though, I wont tell you not to use it or that it will kill you or something like that, im just worried that it might be a risky substance, personally I wouldnt. I prefer seeing a chloride on a Benzodiazepine then 3 on a 2 carbon molecule.

 

[AlphaOdure]

Quake.. haha.. c'mon man, they consider CANNABIS toxic in most western nations, ya know? Why give any validity in their public policy! Even w/ US federal policy! Cannabis is scheduled in the same category (sch I) as diacetylmorphine/heroin, whereas pure methamphetamine is sch II!!!! & relative to each other? meth is much more neuroplastic & potentially damaging relative to diacetylized morphine, ya know? Benzodiazepines aren't an option for me. As i said, i'm on subutex, and i get UAs every month (including thienodiazepines which would include etizolam and benzodiazepines; i know this for a fact). i recognize BZDs are safer...but i just can't use them- yet my dumbass doctor Rx's me a barbiturate!!

And SB- wow, that's fucked up!!! I'm getting powder form, though. Although no doubt its ethanol soluble.. i haven't checked for sure though. However, when hanging out w/ friends who usually drink; i'm going to replace drinking, which i hate by the way, w/ CH if I find it recreational in hourly, lower doses so i don't just end up passing out.

 

[sekio]

Chloral hydrate.
Colourless or white crystals which volatilise slowly on exposure to air and are decomposed by caustic alkalis, liberating chloroform. Mp 50c. Bp 98c. 1 mL of water dissolves the following amounts of cloral hydrate: 2.4 g at 0c, 8.3 g at 25c, 14.3 g at 140c. Soluble: 1 in 0.2 of ethanol, 1 in 1.3 of alcohol, 1 in 2 of chloroform, 1 in 1.4 olive oil, 1 in 0.5 glycerol, 1 in 68 g carbon disulfide and 1 in 1.5 of ether. Freely soluble in acetone and methylethyl ketone. Moderately or sparingly soluble in turpentine, petroleum ether, carbon tetrachloride, benzene, and toluene. Ethanolic solutions may deposit crystals of cloral ethanolate.

Readily absorbed following oral administration. It is rapidly metabolised by reduction to trichloroethanol, the major active metabolite, which is further metabolised by conjugation with glucuronic acid to give urochloralic acid and by oxidation to trichloroacetic acid, the major urinary metabolite. Trichloroethanol passes into the CSF, into breast milk, and across the placenta. About 10–30% of a dose is excreted in the urine as urochloralic acid and up to 5% as trichloroethanol in 24 h. Trichloroacetic acid is slowly excreted in urine over several days; a small amount of urochloralic acid may be excreted in the bile.

Toxicity. Fatalities have occurred following the ingestion of 1.25 and 3 g but recovery has occurred after ingestion of 30 g.

Half-life. Plasma half-life, chloral hydrate about 4 min, trichloroethanol about 7 to 11 h, urochloralic acid about 7 h, trichloroacetic acid about 4 days.

Dose. 0.5 to 2 g daily. Children may be given 30 to 50 mg/kg body-weight with a maximum single dose of 1 g.

Uses. A hypnotic of special value in nervous insomnia, puerperal mania, insanity, and delerium tremens. Small doses produce a sound natural sleep lasting for several hours. Its effect may be enhanced by the addition of morphine or bromide. [Ed. note: don't do this] It is also a valuable sedative against the convulsions of strychnine, tetanus, and eclampsia, and has been employed in asthma and seasickness. Clinical trials show that chloral hydrate in theraputic doses has no harmful effect on the heart. It is a remarkably effective hypnotic almost entirely free from habit formation. [ed. note: yeah right] Its use is best avoided in the presence of gastro-intestinal irritation, though this drawback can be practically eliminated by diluting sufficiently with water. When the blood pressure is lowered during chloral hydrate administration, the effect is not much greater than occurs in natural sleep - actually many patients have an increased blood pressure after taking chloral hydrate. It is used externally as an anodyne and counter-irritant in liniments for rheumatism, sciatica, etc.

Dose. 5 to 20 grains (0.3 to 1.2g) in aqueous solution or in chloroform water, well diluted. P. Helv. V. and P. Dan. have max single dose 45 grains (2.7 g), max during 24 hours 90 grains (5.4g).

Incompatible with alkalis and alkaline salts, ammonium salts, borax, tannin, potassium iodide or permanganate, and with alcohol - chloral-alcoholate may seperate.) Liquifies with camphor and with quinine salts.

Antidotes. [ed. Activated charcoal and careful observation is probably better than the following. I reproduce it here anyway] Empty stomach by emetic or by stomach-tube, using at least 2 gallons of water at 105F. Keep patient lying down and warm with hot blankets and hot water-bottles; he must be roused but not walked about. Give hot, strong coffee; aromatic spirit of ammonia, 1/2 dr. in 4 oz of water. Caffeine sodium benzoate, 2gr (120mg), ad strychnine, 1/8 gr (7.5mg) hypodermically. Oxygen, or oxygen and 7% carbon dioxide inhalations may be needed, also artificial respiration. [ed. After having your gastric contents removed and being filled full of stimulants, you can bet you'd probably need A.R.!]

hope this helps. Chloral hydrate is still used today because it's cheap, effective, and relatively non-toxic. It has been largely supplanted by the benzos, though, partially because trichloroacetic acid and trichloroethanol are not exactly very nice for your cells to deal with. (TCA is used as a weed killer.)

Chloral seems like it isn't very fun. Put it in the phenobarbital bin - effective sedative, but unless you enjoy feeling like your head is full of sand, don't bother using it recreationally.

 

[QUARE]

Chloral seems like it isn't very fun. Put it in the phenobarbital bin - effective sedative, but unless you enjoy feeling like your head is full of sand, don't bother using it recreationally.

lol, that was a funny one. Phenobarbital made me feel retarded for 3 days.

BTW AlphaOdure, Schedule works in term of abuse potential and risk for population, not toxicity. In my country Cannabis is scheduled II and Methamphetamine is sheduled I along with MDPV, Amphetamines, Flunitrazepam, PCP, GHB and every single scheduled Opioids including Codeine. Schedule II only contain Cannabis and its derivative. III contain mostly Psychedelics and IV contain Barbiturates, Benzodiazepines and Steroids than pretty much everything after that are drugs precursor or regulated OTC.

 

[THE_REAL_OBLIVION]

lol, that was a funny one. Phenobarbital made me feel retarded for 3 days.

BTW AlphaOdure, Schedule works in term of abuse potential and risk for population, not toxicity. In my country Cannabis is scheduled II and Methamphetamine is sheduled I along with MDPV, Amphetamines, Flunitrazepam, PCP, GHB and every single scheduled Opioids including Codeine. Schedule II only contain Cannabis and its derivative. III contain mostly Psychedelics and IV contain Barbiturates, Benzodiazepines and Steroids than pretty much everything after that are drugs precursor or regulated OTC.

This simple molecule is still available as a syrup or capsules. I could only get info on the syrup, my step-dad said his dad used cholral hydrate bottles would would break wearing gloves (that came with the script), it would break evenly into a cylinder with the liquid in it and he would take a swill of it all (1000mg, max dose) for a while after his brother died along while ago, but it,s still in the paid medication list, like all of a sudden generic oxycontin (Oxycodone-CR) where the pills are like the CDN's, not OxyNeo, the pdf for october 2018, I always look at the resume of changes, and the best cannabinoid I ever had, a legal one since 1985, Cesamet (Nabilone) is now offered as a generic product. Mixing it with weed when it kicks in 2 hours later would remind one of their first ever highs, that love buzz you get for hash, weed, oil, anything, except Cesamet produces no anxiety at all.

So I got an appnt with my doctor in a few hours, I'll ask him if I can get the capsules or if not the syrup, as it would help me reduce my nightly temazepam intake, not take it every night, which is really why I would want to try it, other options, hydroxyzine and promethazine (oh and buspirone, lol) are in the "Other Sedatives" and the price fluctuations from the last pdf they publish every 3 months or so. I wonder what he'll say, he knows I know a hell lot about neuropharmacology, having passed with a B- 3 years out of the 4 year BSc. It's worth a try, but I also want to try tizanidine (muscle relaxant), that used to be only available as Zanaflex and was rx only, so maybe just asking to renew what was I was supposed to renew, my Mobicox 15mg, my Synthroid and anti-estrogen which is also really anti0 breast cancer for women pills, but it does destroy bumps on one's one small manboobs that refuse to go away, they went away real quickly last time when I added them to the Delastestryl SC then a few weeks of IM until I said fuck it, my T levels being low didn't bother me at all, I could still be interested in sex her, the partner, and i've never even see for curiosity gay porn, so I'm pretty much covered when it comes to estrogen and other environmental and nutrition related hormones messing up your shit.

So yeah, lots of things to ask, maybe I'll ask, normally a visit is 20-25 minutes, but if he has to osculate my small painful bumps on my tiny breasts and do not recommend an ultrasound and an MRI (I've had the CT with iodine), i'm not gonna be happy.