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Misc can memantine reverse methylphenidate tolerance?

I saw a cutting post in PED the other day, I would look there for other stuff, but I would do 100g protein 100g carbs 10g fats a day or something in that neighborhood. Could come down on everything by 25% or so, just depends on how healthily you want to lose the weight and how much exercise you're doing at the same time. Could go up on carbs, towards 150-200g a day if doing cardio.

But I'm probably not the one to ask and it all depends on your body as well.
 
Thanks, so I have been wanting to try magic mushrooms to reap the benefits (emotional, physical and spiritual aspects) from these things. One question, which might sound insane lol. The magic mushroom grow kits, from what I've heard, grow kits are legal in the united states. Yet there is information contradicting that, which says that anything containing psilocybin is illegal to obtain in the usa. Now , grow kits contain mycelium, which contains the compound 'psilocybin'. So I am very confused please help me, thanks a lot.
 
From the papers that I've read, anything that was proved to have a positive effect on memory can, to some extend, reverse stimulant tolerance.
 
I have a question about the DeltaFosB stuff.

Is it a fact that continual use of stimulants actually makes the receptors more sensitive? It sounds unlogical to me.
I'd have assumed that cycling would be best to prevent tolerance.

Also, how does this fit with antipsychotics causing upregulation of dopamine receptors?

To me these 2 things seem to contradict each other. If blocking dopamine with APs causes upregulation then using stimulants shouldn't cause upregulation, too.

I wonder what would happen if you took an antipsychotic for a while and then went back on stims. I wouldn't want to try it but it would be interesting.
 
razorcuts said:
I wonder what would happen if you took an antipsychotic for a while and then went back on stims. I wouldn't want to try it but it would be interesting[/B].
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Nothing good. Anti-psychotics are known to cause damage to those receptors.

razorcuts said:
I have a question about the DeltaFosB stuff.

Is it a fact that continual use of stimulants actually makes the receptors more sensitive? It sounds unlogical to me.
I'd have assumed that cycling would be best to prevent tolerance.
Click to expand...

With stimulants, tolerance occurs when you shock the receptors. For example, if you take an Adderall vacation for 2 weeks, then you take your regular dose of 30mg, you shock the receptors. The sensation you experience is that of over-stimulation, as compared to taking 30mg that day after 30 consecutive days being on 30mg. Not the same sensation, one shocks the receptors, the other doesn't. With opioids, tolerance is built when the dose is maintained constant, not the same.

It's like asking, what can the body resist more, hot water or cold water. Here's an interesting fact:

Body temperature is 37 degrees Celsius (37C): When you put your hand into 52C hot water, you cannot hold your hand in for too long because it burns you. In cold water however, people were able to hold their hand in -30C antifreeze water mixture as long as they could in 52C hot water, after they have to remove it because they either get frost-burn, or, with hot water they get burned. So when you compare the temperature differentials between unbearable cold water vs. unbearable hot water you find:

Hot Water: 52C - 37C(body temp) = 15C
Cold Water: 37C - (-30) = 67C

So the body can handle a 60 degree temperature drop, but it cannot handle a 15 degree temperature increase. Similarly, what applies to opioids you cannot apply it to amphetamines, because the body can handle alot of stimulation, but it cannot handle de-activation as well, and tolerance to that builds much faster, hope it answers the question.
 
This sounds scary.

Then should not doctors warn their patients that in case they take a break they have to taper up their dose?
 
razorcuts said:
This sounds scary.

Then should not doctors warn their patients that in case they take a break they have to taper up their dose?
Click to expand...

What I find most useful is to take small amounts often during the day, I achieve best results that way. I have 3mg Dexedrine caps, sometimes I even take 1/2 or 1/4 of it at a time, depends. Like, I would never take 7.5mg as the 15mg capsule is designed to deliver.
 
Maybe you're a bit too anxious. Or why do you think that 7.5mg would be too much of an instant dose?

Why don't you switch to a time-released drug?
 
razorcuts said:
Maybe you're a bit too anxious. Or why do you think that 7.5mg would be too much of an instant dose?

Why don't you switch to a time-released drug?
Click to expand...

That's not recreationally, it's when I go to work. Recreationally I have to initiate the session with 30mg IR, followed by increments of 15mg IR.
 
What do you experience when you take 30mg IR?

And how long does it take after taking it until you feel something?
I read that amphetamines take around 1,5 hours to peak.
 
Hello ksa, if you've read my protocol, I'll be resuming the usage of mph on oct 15. So wish me luck . Hopefully cardio,noopept (for ltp you get off of cardio which regenerates d2 and d3 plus bdnf benefits), b6 and fish oil. Hopefully I'll be able to get back on my dose of 27 mg er before the tolerance and continue that for another year or so until tolerance kicks in again. Any additional recommendations? Thanks ..
 
Hello guys I came here to inform all of you that I took concerta and it didn't do a damn thing aside from boosting my awareness. Let this be a message for all those people out there, if you are taken off of a stimulant medication, please somehow , someway try to get back on it before the end of 1 month. Otherwise tolerance could be permanent, given the fact that you've been on the drug for 6-12 months. Anything under, you still got a chance. I am disheartened after trying all sorts of remedies to fix this tolerance issue. So please guys, heed to this advice. As far as I'm concerned, I don't know what to do, deepest gratitude for those who've helped me ? . I just don't know if there is hope anymore. Any further input can help.
 
Remember, there is a whole lot more to life than stimulant euphoria. There are also other drugs that can induce euphoria, psychedelics would be my recommendation to explore, there seems to be little tolerance to the euphoric/enjoyable states that they can produce.
 
Yes, took the words right out of my mouth. I am looking forward to dabbling with psychedelics. I suffer from major depressive disorder/gad/sad/ocd , so without mph , my life turns to a hellish nightmare. Also. I want my reality to be deconstructed and reconstructed back again a whole new person. I am particularly interested in magic mushrooms as I've heard NUMEROUS times that they can help cure individuals with ptsd and depression (via neurogenesis, activating dormant parts of your brain, slowing down the anterior cingulate cortex etc). I heard it's unlike lsd, where you can control your trip , shrooms do otherwise. Have you tried magic mushrooms? How did it go? Was the euphoria induced by psilocin itself? or by what you experience mentally on mushrooms? eg. The trip.
 
razorcuts said:
What do you experience when you take 30mg IR?

And how long does it take after taking it until you feel something?
I read that amphetamines take around 1,5 hours to peak.
Click to expand...

I just feel increased heart rate and tingling everywhere but that's not the point, for me, 30mg IR gets me to "Marker 1", which is a psychic plateau from which I can view the idea of a hot woman hurting a man for her pleasure as an arousing event. I just browse for that type of fetish on porn resources. I know I hit the first marker when the videos suddenly increase in both quality and content, and I feel the need to pause. That's the first marker.

Marker 2 is hit when I dose 30mg IR while still being stuck on marker 1. As long as the brain is well rested I can never hit marker 2, so I have to skip 2 or 3 nights. At marker 2, the brain cannot escape this plateau without sleep. This is when it gets interesting, in this phase, I can look at a 30min porn video for 12 hours in a row and always find new and interesting facets about it, constantly pausing. I keep understand it in different ways as I progress forward.

Marker 3 is hit when I skipped over 4 nights in a row and redose 30mg IR. At this point, I no longer require porn or any visual material to feel pleasure. I can experience pleasure so intense I cannot describe in words, without porn, nor any sexual thoughts. So at this point what I feel has nothing to do with women. It's like, sex and women was a path that got me there, but once I'm there, the path I took no longer matter, I am touching the source, and the source has no sex, no right and wrong, no color, no shape, it just is and feels amazing.

I did this thousands of times, so I learned to mark my way and recognize certain things so that I know where I am at all times. When I am in a marker 3 state of mind, things like getting out of bed or getting a bottle of water can seem like an unrealistic achievement, motor functions are impaired, I can drop objects I pick up because I cannot feel them properly in my hand or can't feel if they're hot or cold, so I'm completely dysfunctional, and very little shit do I give :)

So you see, the amphetamine peak or high is irrelevant, what matters is what path you take and when. The total insomnia is an important component too, without it I achieve fuckall, like, it just doesn't work. If I were to just sit in bed the first time I take 30mg IR I would be like, wtf am I doing here...and the whole trip would come to an end. The steps have to be followed in a chronological order or I never get there. If I were to try to get to what I call "the source" without following those steps and just redose 30mg, I would go to the ER and wouldn't even come close to it. It's really a methodology that you devellop by following the rush when the rush happens, not follow it by redosing, follow it mentally. I wouldn't expect anybody to understand this but I put it out here since you asked.

I find people freak out too much due to amphetamines side effect, to the nearest thing they go to the ER. Like, in marker 3, I'm numb to the point where I touch things with my hands and I can't feel shit, and I was in a state like that thousands of times, without any issues. I was like that 2,000x, 3000x or 4,000x, I don't know, I stopped counting, and now I'm perfectly functional. Maybe I'm the guy who didn't die, I don't know, but I think I have a solid method that works for me and with the help of people on this site, I perfected it and made it invulnerable.
 
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