If you mean that your mouth (especially the tongue) can get a bit tingly like when local anaesthesia kicks in (not fully sedated, just kicking in) or like when your foot has fallen asleep and is waking up then yeah I've had that before when I take a huge bong rip or something similar. I think harsh and particularly dense smoke causes some mild irritation, which causes the tingly feeling. If you mean that you actually are a bit sedated in your mouth then no, I have never experienced that from weed alone, that isn't normal I think, but I could be wrong and every person will react slightly different to drugs, so it's possible I guess