@TripSitterNZ would support this suggestion, not by definition what the OP is asking exactly. But curses, or negative energy, can be put into the LSD by nasty folks, be it the chemists or dealers.
Energy is very real, stemming from consciousness often.
So in that sense, it CAN go "bad."
But in terms of "going off" in usual terms...no, I don't think so.
Albert Hofmann stated strongly, that under the right storage conditions, no light, heat, moisture, oxygen...LSD can last indefinitely.
Degradation, i.e. reduction of potency, is acid gone "bad" IMO, not in a harmful sense though. Just less effective.