What does it mean please
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BDD Moderators: Keif’ Richards | negrogesic
Stimulants Caffeine blocks GABAa receptors?
- Thread starter The Holy Quadruplty
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ChemicallyEnhanced
Bluelighter
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What does what mean?
So makes gaba stronger?
ChemicallyEnhanced
Bluelighter
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Not with benzodiazepines or barbiturates (in my experience) but definitely makes Gabapentin/Pregabalin/Phenibut stronger.
ĐmantuNJofra
Bluelighter
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yeah it's synergistic with pregabalin but that was not the point as pregabalin is a2d waves ca+voltage channel blocker and both those are not gabaa agonists just modulating gaba via first mentioned
OP was asking and stating that caffeine works antagonistic on gaba receptors while again the intake should be like very high, or I red wrong?
OP was asking and stating that caffeine works antagonistic on gaba receptors while again the intake should be like very high, or I red wrong?
Jabberwocky
Frumious Bandersnatch
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A billion times no to you, sir; exactly the opposite of what you state is true.
Caffeine prevents the anti-hyperalgesic action of gabapentin.
The activity of gabapentin to reduce hypersensitivity to pain is prevented by caffeine.
Caffeine antagonizes the effects of gabapentin.
Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor - PubMed
This study was designed to determine whether 3 weeks of gabapentin treatment is effective in alleviating neuropathic pain-like behavior in animal models of complex regional pain syndrome type-I and partial sciatic nerve ligation (PSNL). We investigated the contribution of adenosine subtypes to...
pubmed.ncbi.nlm.nih.gov
You probably also suffer under the false assumption that gabapentin affects the GABA receptor, it doesn't, at all. Yes, gabapentin does increase levels of GABA in the brain but it does that independent of activity at the GABA receptor. It's a downstream effect from its action at the alpha-One-Delta-2 receptor.
ChemicallyEnhanced
Bluelighter
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A billion times no to you, sir; exactly the opposite of what you state is true.
Caffeine prevents the anti-hyperalgesic action of gabapentin.
The activity of gabapentin to reduce hypersensitivity to pain is prevented by caffeine.
Caffeine antagonizes the effects of gabapentin.
Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor - PubMed
This study was designed to determine whether 3 weeks of gabapentin treatment is effective in alleviating neuropathic pain-like behavior in animal models of complex regional pain syndrome type-I and partial sciatic nerve ligation (PSNL). We investigated the contribution of adenosine subtypes to...
You probably also suffer under the false assumption that gabapentin affects the GABA receptor, it doesn't, at all. Yes, gabapentin does increase levels of GABA in the brain but it does that independent of activity at the GABA receptor. It's a downstream effect from its action at the alpha-One-Delta-2 receptor.
I literally take gabapentin every day. What I said I 100% correct. Many, many people get the same effect I do. I was speaking about the recreational effects, though. It doesn't seem to affect the analgesic effects either way.
ChemicallyEnhanced
Bluelighter
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^Oh, I do wanna add - for safety reasons - caffeine definitely DOES decrease anti-convulsant effects of Gabapentin, so don't combine it was caffeine if you take it for seizures.