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Caffeine analogs

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yaesutom

Bluelighter
Joined
Oct 15, 2000
Messages
1,730
Has anyone tried any caffeine analogs? It looks like some of them are in some energy / bodybuilding supplements...

http://www.ncbi.nlm.nih.gov/pubmed/3193854

3,7-Dimethyl-1-propargylxanthine (DMPX), a caffeine analog that exhibits in vitro selectivity for A2-adenosine receptors, compared to A1-adenosine receptors, has now been investigated with respect to in vivo potency and selectivity. DMPX potently and selectively blocked the actions of the potent A2 adenosine agonist, 5'-N-ethylcarboxamidoadenosine (NECA), in DBA/2 mice, compared to blockade of the same responses elicited by the selective A1-adenosine agonist, N6-cyclohexyladenosine (CHA). DMPX was 57-fold more potent versus NECA-induced hypothermia than versus CHA-induced hypothermia and 11-fold more potent versus NECA-induced behavioral depression than versus CHA-induced behavioral depression. The hypothermia is mediated by peripheral receptors, based on blockade by 8-(p-sulfophenyl)theophylline (PSPT), while the behavioral depression is centrally mediated, based on lack of blockade by PSPT. DMPX was 28- and 15-fold more potent than caffeine in blocking peripheral and central NECA-responses, respectively. DMPX was equipotent with caffeine versus CHA-induced hypothermia and 2.5-fold more potent than caffeine versus CHA-induced behavioral depression. The motor stimulating potency of DMPX (ED50 10 mumol/kg) was slightly greater than caffeine.
Click to expand...

https://www.google.com/search?q=1,3...rome..69i57&sourceid=chrome&es_sm=93&ie=UTF-8

If some have more selectivity for some receptors, it has me wondering if any of them might have less side effects or be better in some way. Not that caffeine is that great but I am curious.
 
Some time ago I was trying to get some paraxanthine, which is one of the metabolites of caffeine. Couldn't find any (didn't really try too hard though), but what I remember from my research is that it's not as anxiogenic as caffeine and that it's neuroprotective. It also has a shorter half life, so you can dose it closer to your bedtime.

I'm not sure why they don't put that in energy drinks in place of caffeine.

This is a great full-text study on it in narcoleptic nice: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894435/
 
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