http://michaellinnell.org.uk/michae...d_punishment/pdf/CP6_Tart mermaid subutex.pdf
I just wanted to make sure that everyone got the chance to see this great work by a hero of HR, Michael Linnell; a gentleman, a gentle man and a man with the patience to be my friend.
I am sorry if these questions have been asked before but for further research into treatment of opioid dependence, can I ask anyone with personal experience as a user or friend/relative of user. No names, no pack drill.
1)Is buprenorphine euphoric? I was prescribed Temgesic for pain and even 2mg sublingually only gave a light feeling of wellbeing on par with 60mg of DHC. It was quite effective as an analgesic.
2)How does buprenorphine abstinence syndrome compare to that of dihydrocodeine, methadone and morphine?
3)How well does buprenorphine blockade other opioids? I know Suboxone was introduced to prevent euphoria but since it's Ki is similar to that of naloxone and it's T1/2 much longer, I've come across IV usage.
4)Has it been a useful stepping stone to getting off full agonists and/or has it been a stepping stone to full agonists? I have tried many opioids and think it a better option than tramadol, for example.
I am asking these questions as part of research into a possible update on HR information concerning the use of buprenorphine. Since the original booklets, the formulations have changed and new opioids have reached the market. I cannot see a good reason for oxycodone to have been introduced. The BNF specifies it as a second-line drug only to be used after morphine 'or similar high potency opioid' has failed to provide sufficient relief. We also have hydromorphone which from the limited amount I know seems somewhat less abusable than many other potent opioids. I have read many US users saying that hydromorphone is 'all about the rush'. I know oxymorphone is highly prized but I think I have only ever read a single report on Levo Dromoran (levorphanol) and that was oral use. The description was of a classic dual μ/NMDA ligand (long rush & sustained euphoria). Is it so rare that it has never been taken parenterally. This last point is because the UK still has Diconal (dipipanone + cyclizine), Scandinavia still has Ketogan (ketobemidone) and much of Europe still has Dipidolor (piritimide) or Heptalgin (phenadoxone).
At the other end of the spectrum, China widely uses A-237 (1-butyryl-4-cinnamylpiperazine) which appears to be another partial agonist although derivatives listed on the Eunoia Disc show some quite potent derivatives. If they are still partial agonists, they may be of some utility.
I thank you all for your time and if the booklet does end up being printed, how shall I best credit people?
I just wanted to make sure that everyone got the chance to see this great work by a hero of HR, Michael Linnell; a gentleman, a gentle man and a man with the patience to be my friend.
I am sorry if these questions have been asked before but for further research into treatment of opioid dependence, can I ask anyone with personal experience as a user or friend/relative of user. No names, no pack drill.
1)Is buprenorphine euphoric? I was prescribed Temgesic for pain and even 2mg sublingually only gave a light feeling of wellbeing on par with 60mg of DHC. It was quite effective as an analgesic.
2)How does buprenorphine abstinence syndrome compare to that of dihydrocodeine, methadone and morphine?
3)How well does buprenorphine blockade other opioids? I know Suboxone was introduced to prevent euphoria but since it's Ki is similar to that of naloxone and it's T1/2 much longer, I've come across IV usage.
4)Has it been a useful stepping stone to getting off full agonists and/or has it been a stepping stone to full agonists? I have tried many opioids and think it a better option than tramadol, for example.
I am asking these questions as part of research into a possible update on HR information concerning the use of buprenorphine. Since the original booklets, the formulations have changed and new opioids have reached the market. I cannot see a good reason for oxycodone to have been introduced. The BNF specifies it as a second-line drug only to be used after morphine 'or similar high potency opioid' has failed to provide sufficient relief. We also have hydromorphone which from the limited amount I know seems somewhat less abusable than many other potent opioids. I have read many US users saying that hydromorphone is 'all about the rush'. I know oxymorphone is highly prized but I think I have only ever read a single report on Levo Dromoran (levorphanol) and that was oral use. The description was of a classic dual μ/NMDA ligand (long rush & sustained euphoria). Is it so rare that it has never been taken parenterally. This last point is because the UK still has Diconal (dipipanone + cyclizine), Scandinavia still has Ketogan (ketobemidone) and much of Europe still has Dipidolor (piritimide) or Heptalgin (phenadoxone).
At the other end of the spectrum, China widely uses A-237 (1-butyryl-4-cinnamylpiperazine) which appears to be another partial agonist although derivatives listed on the Eunoia Disc show some quite potent derivatives. If they are still partial agonists, they may be of some utility.
I thank you all for your time and if the booklet does end up being printed, how shall I best credit people?
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