citypress100
Bluelighter
- Joined
- Mar 21, 2023
- Messages
- 44
Hi again my awesome Chemists: Have been reading this journal regarding removal of levamisole from organic compounds : https://www.dea.gov/sites/default/files/pr/microgram-journals/2013/mj10-1_12-16.pdf
At the end of page 13, the method reads:
" Each of the cocaine HCl/tetramisole HCl mixtures (85:15, 70:30, 50:50) were converted to the base form by dissolving the mixture in boiling water and adding dilute ammonium hydroxide until the solution was basic and precipitation occurred. The mixture was allowed to cool, and the water was removed. The remaining base mixture was allowed to dry overnight. "
Basically, it's just turn the HCl into base, but I am curious about their methods
My questions are, Part 1- what is the correct setup for the boiling water mix they used - is it simply a boiling tube or would they have used a reflux condenser?
Part 2 - Removal of water - they make this sound very simple - is it just a case that the water layer would be separate and could be removed via syringe/pipette - or is there a different technique?
At the end of page 13, the method reads:
" Each of the cocaine HCl/tetramisole HCl mixtures (85:15, 70:30, 50:50) were converted to the base form by dissolving the mixture in boiling water and adding dilute ammonium hydroxide until the solution was basic and precipitation occurred. The mixture was allowed to cool, and the water was removed. The remaining base mixture was allowed to dry overnight. "
Basically, it's just turn the HCl into base, but I am curious about their methods
My questions are, Part 1- what is the correct setup for the boiling water mix they used - is it simply a boiling tube or would they have used a reflux condenser?
Part 2 - Removal of water - they make this sound very simple - is it just a case that the water layer would be separate and could be removed via syringe/pipette - or is there a different technique?
