Bioavailability concerns are a hot topic here. If this is of interested, read on.

[teritanonasentia]

A solid background in organic chemistry is required to gain the most benefit from these papers, however, each of them outlines ways of increasing solubility of various substance through the use of organic chemical techniques. Anyone who has shot 50/50 pure grain alcohol and water solution in an attempt to increase solubility will agree that it is not a very pleasant option. Techniques range from the use salts, ph modification of the solvent and move rapidly into serious organic chemical procedures requiring at least a rudimentary understanding of organic laboratory technique.

The first article has proven useful. The others I have not read as deeply.

http://www.academia.edu/2611991/TEC...HANCEMENT_OF_POORLY_SOLUBLE_DRUGS_AN_OVERVIEW

I hope that this answers some of the questions popping up, especially regarding the notoriously insoluble benzodiazepines. Unfortunately, organic systems don't take well to good strong solvents like benzene or mineral alcohol.

These others may prove of benefit for explorers willing to get their feet wet in the realm of organic chem.

http://capsugel.com/media/library/when-poor-solubility-becomes-an-issue-from-early-stage-to-proof-of-concept.pdf
http://www.merckmanuals.com/vet/pha...uction/dosage_forms_and_delivery_systems.html

I am not a doctor. I do not recommend you follow any of these procedures unless you are appropriately licensed, trained and have consulting your physician first. These resources are provided in a purely informational capacity.

Ta ta

Vixen

 

[DocDRDoc]

Very, very nice information at hand.

Thanks for posting this, this could help a lot of "curious" people around here or even people just trying to be more efficient. 8)