IndigoDahli
Greenlighter
- Joined
- Jul 6, 2016
- Messages
- 4
Hey there. I have been doing some extensive research on the mechanisms of action of Lorazepam, Pregabalin, and Gabapentin. Also, incorporating Kava Kava into my daily therapeutic regimen. I wanted the communities insight in how to maximize the effect of each of these compounds (Kava Kava having multiple psychoactive compounds).
I know that Pregabalin will displace Gabapentin at the Alpha 2 Delta protein (the auxiliary sub-unit that modulates voltage-gated calcium channels). Will any Gabapentin still be active or does the Pregabalin completely displace the Gabapentin? Will Lorazepam displace Pregabalin? or since Lorazepam binds to the Benzodiazepine site and modulates the GABA type A receptor (GABAA), that Lorazepam and Pregabalin can be taken in conjunction with one another without any binding issues or possible receptor displacement?
Also, would staggering Gabapentin doses AFTER ingesting Pregabalin increase the effect on the Alpha 2 Delta protein? Or would the Pregabalin binding affinity be so much higher, rendering any further Gabapentin dosing ineffective?
Also, how would the multiple psychoactive compounds of Kava Kava (some GABAergic) influence Lorazepam, Pregabalin, and Gabapentin? Would there be any binding or displacement issues combining Lorazepam, Pregabalin, and Gabapentin with any of the Kavalactones?
-Indigo
I know that Pregabalin will displace Gabapentin at the Alpha 2 Delta protein (the auxiliary sub-unit that modulates voltage-gated calcium channels). Will any Gabapentin still be active or does the Pregabalin completely displace the Gabapentin? Will Lorazepam displace Pregabalin? or since Lorazepam binds to the Benzodiazepine site and modulates the GABA type A receptor (GABAA), that Lorazepam and Pregabalin can be taken in conjunction with one another without any binding issues or possible receptor displacement?
Also, would staggering Gabapentin doses AFTER ingesting Pregabalin increase the effect on the Alpha 2 Delta protein? Or would the Pregabalin binding affinity be so much higher, rendering any further Gabapentin dosing ineffective?
Also, how would the multiple psychoactive compounds of Kava Kava (some GABAergic) influence Lorazepam, Pregabalin, and Gabapentin? Would there be any binding or displacement issues combining Lorazepam, Pregabalin, and Gabapentin with any of the Kavalactones?
-Indigo