Limpet_Chicken
Bluelighter
- Joined
- Oct 13, 2005
- Messages
- 6,323
Reportedly betulin, derived from the bark of the common birch tree (is it also present in silver birch? there are far more commonly found here than the brown type. Suits me usually mind you, for it means every year brings in a bumper harvest of fly agaric and its parasitic bolete 'friend' Chalciporus piperatus, peppery boletus, which I just love to powder up in my spice grinder with cured fly agaric and throw some in the pot while making chilli con carne
gives it a lovely fire that can't be quite replicated by other spices. If it wasn't a parasite on a mycorrhizal mushroom, I'd suggest it be sold in supermarkets as a spice, as its quite lovely with meat, especially with a bit of fly Amanita. Nature is telling something by bringing these together as a pair%)
Anyhow, betulin itself forms up to 30% dry weight of birch bark although reportedly, its not very orally bioavailable, still, theres no shortage of the stuff if I go looking..(its been extensively explored as a lead compound for developing a really wide range of all kinds of drug, antiretrovirals, antiprotozoals, topoisomerase inhibitors and more besides.
https://www.infona.pl/resource/bwmeta1.element.elsevier-cb41d204-2878-3573-a573-0f2461a158a2
Question-is bicucculine an allosteric or orthosteric GABAa antagonist? which binding site does it hit because its competitive with betulin, I just want to figure out if its likely to be benzo-like or more like a barbiturate/chlormethiazole
gives it a lovely fire that can't be quite replicated by other spices. If it wasn't a parasite on a mycorrhizal mushroom, I'd suggest it be sold in supermarkets as a spice, as its quite lovely with meat, especially with a bit of fly Amanita. Nature is telling something by bringing these together as a pair%)
Anyhow, betulin itself forms up to 30% dry weight of birch bark although reportedly, its not very orally bioavailable, still, theres no shortage of the stuff if I go looking..(its been extensively explored as a lead compound for developing a really wide range of all kinds of drug, antiretrovirals, antiprotozoals, topoisomerase inhibitors and more besides.
https://www.infona.pl/resource/bwmeta1.element.elsevier-cb41d204-2878-3573-a573-0f2461a158a2
Question-is bicucculine an allosteric or orthosteric GABAa antagonist? which binding site does it hit because its competitive with betulin, I just want to figure out if its likely to be benzo-like or more like a barbiturate/chlormethiazole