K'd-OUT-in-AZ
Bluelighter
- Joined
- Jul 11, 2008
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- 5,773
Intravenously (and probably intranasally), oxycodone then oxymorphone then hydromorphone would be your best bets regarding duration. They are all very strong opiates. Potency is sort of irrelevant, it's mostly therapeutic index that counts regarding strength. Of course, time release formulations are much better for long term pain. Does pharmaceutical fentanyl even come IR?
What? Are you kidding? The bioavailability of oxycodone intranasally is worse than oral and it only increases a little via IV as it already has a high oral bioavailability. Oxymorphone IV is 20 times more potent than oxycodone and while you won't find much information on IV oxycodone, its potency doesn't increase much higher than its oral route because of its already high BA. Oxycodone would by far be last behing IV oxymorphone and hydromorphone. Oxymorphone would be first because it becomes ten times stronger when IV'd than its oral route (1 mg IV=10mg oral), hydromorphone increases 5 times (1mg IV=5mg Oral) and Oxycodone probably 2 or 3 times (1mg IV=2-3mg Oral). Oxycodone is a prediction but it wouldn't become more than 3 times.