Benzos Benzos for comedown of methylphenidate

[Rafayte]

I have been 48 hours snorting methylphenidate with some oral dose and only rest two lines. For the comedown I have 4mg Xanax and Tranxene 50mg, how much must I take for avoid comedown?

 

[Rafayte]

Xanax orally or sublingual

I am in the comedown of a heavy methylphenidate use and I have two 2mg Xanax tablets and I don't know if swallow it or take it sublingual. What ROA is more powerful?

 

[Jabberwocky]

They are about the same. Sublingual use tends to come in a little faster, and bioavailability might be a tad higher than oral use, but I rarely noticed a huge difference. That said I always preferred sublingual use.

 

[Jekyl Anhydride]

They are about the same. .

Pretty much this^. But if you want a tiny edge or trade-off take a read. And if you mess with cyp3A4 or 2D6 then you have to drink the Grapefruitjuice 24 hours in advance for max bergamottin effect.

https://www.ncbi.nlm.nih.gov/pubmed/3680603

 

[Jabberwocky]

Iono, I was able to potenriate buprenorphine successfully taking cimetidine just before dosing, but I guess that was always sublingual dosing. Iirc I probably did administer it like 30-45 minutes prior to insulfating buprenorphine.

Thanks for the study

 

[Coolwhip]

Xanax tastes terrible, no reason to subject yourself to SL, now if you had some minty fresh clonazepam that would be a different story.

 

[LesFleursDuMal]

Methylphenidate doesn't generally have a harsh comedown like methamphetamine or cocaine might. It's not pleasant but you can get away with taking just near the same dosage of alprazolam you normally would to achieve relaxation for the comedown off methylphenidate.

 

[Pickledlemons]

Methylphenidate doesn't generally have a harsh comedown like methamphetamine or cocaine might. It's not pleasant but you can get away with taking just near the same dosage of alprazolam you normally would to achieve relaxation for the comedown off methylphenidate.

Really? I disagree. I think methylphenidate has the worst comedown of the 3.