Somberlain
Bluelighter
- Joined
- Oct 29, 2012
- Messages
- 89
Sorry, i don't want this to come through like another of those stupid snorting/shooting/plugging benzos-questions. But propably it is pretty much that. Anyway...
I have Bromazepam and i found reports where they compared the effects of oral and rectal administration of Bromazepam in animals. As far as i understood it, they came to the conclusion that it might be a good idea to make it available as a preparation for rectal administration because their results showed, that it was sometimes superior to oral administration (e.g. lower doses for same effect, faster onset or something like that, can't remember the details).
Unfortunately, i couldn't find any info on how they prepared the substance für rectal administration. I don't know about Bromazepam's bioavailability or (more important) solubility in water, how the pH influences it and if water could be used at all or if it's only soluble in other solvents. Since it isn't even mentioned in this thread, i suppose it's pretty un-soluble without the right equipment/substances, but i would love to get some input from you more experienced guys.
To give you at least some kind of explanation why i'm interested in it: I'm not necessarily looking for some kind of rush, or want to do it because just taking them oral is boring or something like that. I'm looking into this ROA for Bromazepam since i read this report about its possible advantages mainly because my supply is VERY limited. If there was a way i could use (for example) 3mg for a situation which normally would require me to take a full 6mg... this would be f'ing amazing.
So, Bromazepam seems "almost unsoluble" (dont' know what "almost" exactly means here) in water and i only found out it is soluble in methanol, which isn't very practible for making a solution i imagine. Any ideas/input?
edit: Their conclusion was: "From these data, significant differences of the pharmacological effects between oral and rectal administration of bromazepam were recognized in the duration of action and, in part, potencies; and therefore, rectal administration of bromazepam may be a useful dosage form for clinical use." That's why i thought it might be worth a try, but i'm afraid that making a solution for this ROA is a bit complicated.
I have Bromazepam and i found reports where they compared the effects of oral and rectal administration of Bromazepam in animals. As far as i understood it, they came to the conclusion that it might be a good idea to make it available as a preparation for rectal administration because their results showed, that it was sometimes superior to oral administration (e.g. lower doses for same effect, faster onset or something like that, can't remember the details).
Unfortunately, i couldn't find any info on how they prepared the substance für rectal administration. I don't know about Bromazepam's bioavailability or (more important) solubility in water, how the pH influences it and if water could be used at all or if it's only soluble in other solvents. Since it isn't even mentioned in this thread, i suppose it's pretty un-soluble without the right equipment/substances, but i would love to get some input from you more experienced guys.
To give you at least some kind of explanation why i'm interested in it: I'm not necessarily looking for some kind of rush, or want to do it because just taking them oral is boring or something like that. I'm looking into this ROA for Bromazepam since i read this report about its possible advantages mainly because my supply is VERY limited. If there was a way i could use (for example) 3mg for a situation which normally would require me to take a full 6mg... this would be f'ing amazing.
So, Bromazepam seems "almost unsoluble" (dont' know what "almost" exactly means here) in water and i only found out it is soluble in methanol, which isn't very practible for making a solution i imagine. Any ideas/input?
edit: Their conclusion was: "From these data, significant differences of the pharmacological effects between oral and rectal administration of bromazepam were recognized in the duration of action and, in part, potencies; and therefore, rectal administration of bromazepam may be a useful dosage form for clinical use." That's why i thought it might be worth a try, but i'm afraid that making a solution for this ROA is a bit complicated.