Clonidine was made to treat high blood-pressure, the other two work the same way, although tizanidine is used as a muscle relaxant so they have probably tested it better for usage unrelated to blood pressure. However lofexidine should be the best for withdrawal since they had it in mind when they made it. If you find yourself not being prescribed any of them, go to another doctor, complain of recurring muscle pain and ask for tizanidine (brand name, never drug name) specifying you've been prescribed valium and flexeril and they were WAY too sedating and last time the doctor gave you tizanidine and it worked great. Doctors like to prescribe less addictive options when you... push them in the right direction.
As for my post, it was kinda dickish look back on it and I apologize. But be careful with these drugs, they do have CNS effects as well, in fact the imidazoline receptor was discovered because of clonidine, and most importantly, they can easily cause hypotension if you double dose or mix with alcohol, even more so than benzos. Benzos really make no sense as withdrawal medications, their role with alcohol is more akin to drug replacement therapy. Baclofen is quite interesting, given it's used for cocaine, alcochol, opioids and it seems to lower cravings. Worth checking out. And although Phenibut has a very similar structure, phenibut is a weak gabapentoid in practice, while baclofen is a GABA B agonist, so very different.
