Benzos Benzodiazepine Alternatives?

[Blirna]

1. Could someone please give me some names for some RCs or Benzodiazepine derivatives that work like benzodiazepines, but aren't chemically structurally similar? I can't fail a drug test for Benzodiazepines, is why I'm asking that.
2. What are some RCs/Nootropics that work similarly to Gabapentinoids, Benzodiazepines, or on GABA in any way, that leads to anxiolytic effects? I know about Phenibut and F-Phenibut, but is there anything else? I would love some of the newly developed Gabapentinoids, such as Imagabalin, Atagabalin, 4-Methyl-Pregabalin, PD-217,01 (Currently being researched), Mirogabalin, or anything similar, but I just can not find them anywhere for purchase. I heard Tolibut is available, but I don't know where to look.
3. Nonbenzodiazepines or derivatives would work, too.

What I'm hoping to gain by asking this is some kind of drug that will get rid of my anxiety, because my Nurse Practitioner won't RX Pregabalin anymore, ever since it went to Schedule V, and the whole clinic adopted a no-Benzodiazepine policy, so that is out the window for me. If I could just get this anxiety under control, I would be able to live my life so much easier and be more productive. I'm having to depend on Gabapentin for my anxiety, but tolerance goes up easily with it, and it doesn't make you feel good for very long. Anxiolytic effects seem to be more pronounced when you can feel the medication, rather than taking it like an SSRI.

Please, somebody, recommend me SOMETHING that can save me from this hell.. I'm tired of feeling like this, worrying about bullshit thoroughly,regardless of how insignificant, always being scared to go outside, paranoia, the terrible burning in my chest that feels like my blood is on fire... All of it. I'm about ready to just give up. I tend to get suicidal when the anxiety gets out of hand, rather than due to depression..

Sorry for such a long post. Any help will be deeply appreciated, and you could be saving me from this hell.

 

[Jaredborgetti]

Valerian root has helped me in the past but I doubt it will do shit for you if you want a benzodiazepeine-like experience, it helps with anxiety and I believe it acts on GABA on some way, other than that, exercise is EXTREMELY helpful for anxiety and I can vouch for that since I have extreme anxiety and intense exercise works better than benzos for me.

 

[Neopunk]

Phenibut often was a great help in social situations that would normally make me anxious.

 

[Hodor]

Can't you see a specialist to get a script for pregabalin?

RC gabapentinoids (with the exception of phenibut/F-phenibut) aren't being made because there is little financial incentive to do so. Phenibut may be weak on a mg-for-mg basis, but atleast it is easy as hell for a lab to synthesize. Something like mirogabalin? Not so much. And when you're dealing with a drug that requires doses of several hundred milligrams on a daily basis, that's kind of an issue.

 

[Blirna]

Can't you see a specialist to get a script for pregabalin?

RC gabapentinoids (with the exception of phenibut/F-phenibut) aren't being made because there is little financial incentive to do so. Phenibut may be weak on a mg-for-mg basis, but atleast it is easy as hell for a lab to synthesize. Something like mirogabalin? Not so much. And when you're dealing with a drug that requires doses of several hundred milligrams on a daily basis, that's kind of an issue.

I asked for substances similar in effects because Benzos are the only thing that have ever helped, along with Gabapentinoids. I havae to take regular urine tests, so I can't have anything that will show up as anything, or I run the risk of 32 months in jail..

I used to get Rxed Pregabalin for my anxiety, but my Psych and Nurse Practitioner don't believe it helps with anxiety, so when I finally got a Rx for it from a Psych unit again recently, they immediately took me off. They won't Rx me any Controlled Substances, as I was dirty for Alprazolam, when I was Rxed Clonazepam. I didn't even know they were giving me a compliance test or that I would have to do such a thing. They have fucked me big time. It was only a one-time thing, too. Worst timing ever...

What kind of specialist did you mean?

I used to be on Clonazepam 1mg 3x/day, Pregabalin 150mg 3x/day, and they rotated me from Temazepam 30mg at night, to Triazolam .5mg, and Ambien 10mg, but when I lost my Bluecross Blueshield insurance, I had to find somewhere cheap that would take medicaid, and they took me off all of it. I want a new Psychiatrist, but I have to get a referral from my GP to a Psychiatrist that will take it, and my GP is a preachy person who believes God can help with anxiety, so... I'm kind of screwed at the moment..

I have some F-Phenibut at the moment, but i haven't found it to be helpful at all.. I'd like to find a vendor for GABOB so I can try that, but it's like searching for a needle in a haystack.. Everywhere is out of stock.

 

[Jaredborgetti]

I understand your situation, anxiety is crippling, but given your current situation wouldnt a non chemical alternative be more realistic? I dont think its realistic to self medicate for the rest of your life with bizarre research chemicals which nobody knows jack shit what consequences they will bring to your organism.

 

[Jaredborgetti]

Even benzos increase cancer and alzheimer risk when used for long periods and they are considered "safe" drugs, let alone uncontrolled research chemicals.

 

[Burnt Offerings]

Normally I'd just suggest shopping around until you get what you want, but it sounds like you're ensnared in the justice system in some way? Are you on probation or something?

Unfortunately there really are no alternatives to benzodiazepines, in terms of safety, availability & efficacy.

 

[zagor11]

use gabapentin

 

[Prescottdave]

Hands down a legal script for gabapentin would be the way to go. Lyrica is scheduled in many states so that could be why it was discontinued as a viable option for you.

 

[zagor11]

Benzo replacement drugs is said to have benzo like effects but not the high.I take PROPRANOLOL and it doesn't make me high but calm and relaxed.

 

[kleinerkiffer]

This thread is borderline against the rules as it's pretty much a "What should I take" thread and you want to use the info to take drugs and still pass a drug test, but I can relate to having extremely bad anxiety, so I'll let this thread stay open for some time

 

[Keif' Richards]

In my opinion, the Gabapentinoids are the most logical step down from Benzodiazepines. You'll find in medical literature that Pregabalin (Lyrica) is an effective anxiolytic for a lot of people. The Gabapentinoids have the added benefit of being slightly less prone to abuse and dependence. The withdrawal syndrome from either Pregabalin or Gabapentin (Neurontin) can indeed be a highly unpleasant experience, but is not likely to require any kind of medical intervention.

I have issues with anxiety. This, coupled with what I believe to be Depression has been a major driving force in my desire to use mind-altering substances. I can't control my Alcohol intake. I can't really control my intake of Opioids or Benzodiazepines for that matter. With Gabapentinoids, I somehow get a lot of relief but am still able to use my prescription in a responsible way. Essentially, Gabapentinoids and Cannabis are the only two drugs that I have any kind of handle on. This is my form of sobriety. I'm in control with this combination.

Pregabalin has been the most effective psychoactive medication that I have every tried. There is medical literature supporting this stance not to mention Pregabalin's use in detoxifying Alcoholics and keeping them sober. Pregabalin has been shown to reduce instances of relapse in chronic Alcoholics. It has definitely been a life-changing thing for me. After years of trying medication after medication, to find one that actually works felt like staring a fucking unicorn in the eye.

Here are some cool likes that you guys can all check out if you have not already.

https://www.ncbi.nlm.nih.gov/pubmed/23132700

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124051/

 

[Jekyl Anhydride]

While Pregabalin sounds like the best option, it doesn't seem feasible in your current situation.

I used to get Rxed Pregabalin for my anxiety, but my Psych and Nurse Practitioner don't believe it helps with anxiety, so when I finally got a Rx for it from a Psych unit again recently, they immediately took me off

While we can't give you tips on how to influence your healthcare providers to prescribe something more desirable or suggest illicit or grey market sources, I don't think it would be an egregious violation to recommend that you get away from your nurse practitioner and somehow find a medical Doctor over an NP that might understand the complexities of what's going on. One who preferably doesn't mix religion with health care.

Is it possible to switch to a different primary care Physician with your current legal situation/ parole agreement?

 

[Burnt Offerings]

Yeah it's an interesting drug, I know that pregabalin is approved in the EU for treatment of "generalized anxiety disorder". I think that the only approved conditions in the USA are diabetic neuropathy and fibromylagia, though. It's too bad, could be an alternative for people who aren't interested in the more traditional treatments of GAD (like SSRIs and Xanax)

 

[Jaredborgetti]

Pregabalin is shit, its OTC here in my country and still doctors do not prescribe it, its not meant to be used daily, it is nephrotoxic, both capable of causing acute kidney injury and chronic kidney disease, it can also cause severe seizures at high dosages, and the OP was already on 450mg daily of pregabalin according to himself, on top of gobbling benzos like candy (3mg clonazepam daily), gabapentin is much weaker than pregabalin and as I said he was taking 450mgs of pregabalin plus 3mg of clonazepam, it is unsafe and irresponsible to suggest he should take high dosages of a dangerous med like pregabalin or gabapentin, benzos are the safest drug as far as what you are looking for PERIOD, yes they increase cancer risk and alzheimers risk on top of a myriad of other problems but if you are unable to live your life any other way there is no safe and logical solution other than seeking benzos, there are plenty of safe anxioltyics such as valerian root and several approaches to treating anxiety such as exercise but you are clearly wanting a powerful psychoactive drug to control your anxiety, stop recommending pregabalin and gabapentin he was already on almost half a gram of pregabalin daily on top of 3 mgs clonazepam which is already a high dose, its irresponsible to suggest using high dosages of pregabalin which is nephrotoxic and can cause seizures.

 

[Jaredborgetti]

And before someone says its used to treat seizures... yes simple seizures on low dosages, at high dosages it is proconvulsant, you can read hundreds of stories of kids who thought tripping on 600mg or 700mgs of lyrica was a good idea and ending up in the hospital with grand mal seizures, as well as some medical reports of pregabalin worsening seizure disorders even in recommended dosages much lower than the OP took and of kidney injury, actually lyrica is absolutely a NO NO if estimated glomerular filtration rate is less than 60ml/min due to potential of kidney failure and the drug building up and causing neurotoxicity.

 

[Keif' Richards]

Pregabalin is shit, its OTC here in my country and still doctors do not prescribe it, its not meant to be used daily, it is nephrotoxic, both capable of causing acute kidney injury and chronic kidney disease, it can also cause severe seizures at high dosages, and the OP was already on 450mg daily of pregabalin according to himself, on top of gobbling benzos like candy (3mg clonazepam daily), gabapentin is much weaker than pregabalin and as I said he was taking 450mgs of pregabalin plus 3mg of clonazepam, it is unsafe and irresponsible to suggest he should take high dosages of a dangerous med like pregabalin or gabapentin, benzos are the safest drug as far as what you are looking for PERIOD, yes they increase cancer risk and alzheimers risk on top of a myriad of other problems but if you are unable to live your life any other way there is no safe and logical solution other than seeking benzos, there are plenty of safe anxioltyics such as valerian root and several approaches to treating anxiety such as exercise but you are clearly wanting a powerful psychoactive drug to control your anxiety, stop recommending pregabalin and gabapentin he was already on almost half a gram of pregabalin daily on top of 3 mgs clonazepam which is already a high dose, its irresponsible to suggest using high dosages of pregabalin which is nephrotoxic and can cause seizures.

There is so much misinformation in this post man. I don't even really know what to say to this. Benzodiazepines cause cancer and Alzheimer's? Do you have references for this statement? You're telling him that the most logical thing to do in his life is to seek out and use highly addictive sedatives. Do you honestly think this is a solid life plan to give someone that you don't even truly know?

Pregabalin (Lyrica) is toxic to the Kidneys? That's an interesting take on things. Do you have references for this statement? You produce this misinformation and conjecture with such gusto and confidence that it's almost a shame to have to tell you that you are utterly wrong.

 

[Jekyl Anhydride]

Pregabalin is shit, it is unsafe and irresponsible to suggest he should take high dosages of a dangerous med like pregabalin or gabapentin.

After more than a decade of experience with pregabalin, experience and studies have shown that the adverse effect profile of pregabalin is well tolerated for the management of neuropathic pain and other conditions. Its use is associated with benign central nervous system and systemic adverse effects, and there are very limited metabolic, idiosyncratic or known teratogenic adverse effects.

Along with its efficacy in particular neuropathic pain conditions, pregabalin's safety led it to be one of the first pharmacotherapies considered for the management of neuropathic pain.In addition, PGB is used frequently in the treatment of anxiety.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110876/

Sure Pregabalin can cause terrible things like kidney issues or Stevens-Johnson syndrome, but only in very rare cases making it no more dangerous than about 80 % of the other meds out there.

 

[kleinerkiffer]

Pregabalin is shit, its OTC here in my country and still doctors do not prescribe it, its not meant to be used daily, it is nephrotoxic, both capable of causing acute kidney injury and chronic kidney disease, it can also cause severe seizures at high dosages, and the OP was already on 450mg daily of pregabalin according to himself, on top of gobbling benzos like candy (3mg clonazepam daily), gabapentin is much weaker than pregabalin and as I said he was taking 450mgs of pregabalin plus 3mg of clonazepam, it is unsafe and irresponsible to suggest he should take high dosages of a dangerous med like pregabalin or gabapentin, benzos are the safest drug as far as what you are looking for PERIOD, yes they increase cancer risk and alzheimers risk on top of a myriad of other problems but if you are unable to live your life any other way there is no safe and logical solution other than seeking benzos, there are plenty of safe anxioltyics such as valerian root and several approaches to treating anxiety such as exercise but you are clearly wanting a powerful psychoactive drug to control your anxiety, stop recommending pregabalin and gabapentin he was already on almost half a gram of pregabalin daily on top of 3 mgs clonazepam which is already a high dose, its irresponsible to suggest using high dosages of pregabalin which is nephrotoxic and can cause seizures.

Can you post any (peer-reviewed) sources to back up your claims?