katamaranas
Greenlighter
- Joined
- Feb 2, 2015
- Messages
- 18
Do you agree with such statement that to use pregabalin and diazepam together as codeine (in todays case dihydrocodeine) potentiator is not worth ? :
''Pregabalin is the issue, it is interfering with what the Diazepam is made to do and to a lesser extent with the Codeine.
Pregabalin promotes neuralplasticity and do a lot of other regenerative processes with dendrites, axons within the nerve cells. Now in order to do that it uses the building blocks and precursors of Gaba and Gaba itself. It a very potent Gaba1, Gaba2 reuptake inhibitor and agonist.
Now the Diazepam is trying to antagonise all the Gaba1 and Gaba2 it can which gives you the chilled out effect and now in contrast the Pregabalin in promoting the creation of new Gaba1 and Gaba2 and also takes hold of the ones already floating around within the synaptic cleft and don't let them get re-absorbed and broken down and reused again.
Essentially they cancel each other out, almost completely to the point that you hypothetically didn't even take them in the first place.
It is only the Codeine working giving you some buzz because it's main job is u-opiod receptors in the thalamus and amigdala and other regions far from where Gaba shit is going on.''
''Pregabalin is the issue, it is interfering with what the Diazepam is made to do and to a lesser extent with the Codeine.
Pregabalin promotes neuralplasticity and do a lot of other regenerative processes with dendrites, axons within the nerve cells. Now in order to do that it uses the building blocks and precursors of Gaba and Gaba itself. It a very potent Gaba1, Gaba2 reuptake inhibitor and agonist.
Now the Diazepam is trying to antagonise all the Gaba1 and Gaba2 it can which gives you the chilled out effect and now in contrast the Pregabalin in promoting the creation of new Gaba1 and Gaba2 and also takes hold of the ones already floating around within the synaptic cleft and don't let them get re-absorbed and broken down and reused again.
Essentially they cancel each other out, almost completely to the point that you hypothetically didn't even take them in the first place.
It is only the Codeine working giving you some buzz because it's main job is u-opiod receptors in the thalamus and amigdala and other regions far from where Gaba shit is going on.''