Synaps3
Bluelighter
- Joined
- Sep 14, 2011
- Messages
- 257
I am interested in the pharmacology of barbiturates just because they are so old and esoteric.
I am mostly wondering what the N substitution does. Sometimes you'll see a barb with an N methyl. What is the purpose of that? Does it change the duration of action or the effects?
What I know so far is that the longer the upper chains, the more potent, but the shorter the duration. A thiourea makes the duration extremely short.
What I find confusing though is the structure of the carbon chains. Couldn't they just use propyl, butyl, etc? Why do they use weird things such as sec-butyl? Does that change the effects or only the duration?
I am also interested to hear experiences if anyone has tried more than one barb. Are there any barbs that completely lack hypnotic action and are pretty clear headed like 2m2b?
Does anyone have JPET?
Sci-hub doesn't work for it.
I am mostly wondering what the N substitution does. Sometimes you'll see a barb with an N methyl. What is the purpose of that? Does it change the duration of action or the effects?
What I know so far is that the longer the upper chains, the more potent, but the shorter the duration. A thiourea makes the duration extremely short.
What I find confusing though is the structure of the carbon chains. Couldn't they just use propyl, butyl, etc? Why do they use weird things such as sec-butyl? Does that change the effects or only the duration?
I am also interested to hear experiences if anyone has tried more than one barb. Are there any barbs that completely lack hypnotic action and are pretty clear headed like 2m2b?
Does anyone have JPET?
Sci-hub doesn't work for it.