These are my notes for my doctor
- Organisation of thoughts
- Less fidgeting, twitching and teeth grinding, but not enough to stop it
- Concentration is slightly improved, but not enough to watch a full movie or read a whole chapter of a book
- Tolerance will slowly build up, this was the first time taking the medication, so many not be as effective later
-Agitation from not being dosed high enough, needed injectable lorazepam to calm down
- Effects starting at 3 hours last 3 hours thereafter
- Equivalent to 5mg Dexedrine or 10mg Adderall, which are commonly dosed at 15mg and 30mg respectively
- Stops me from feeling like thoughts are being read
- Improves visual snow syndrome
- Can't be abused as its a prodrug, cannot be snorted and overdose is hard since only so many enzymes in red blood cells to break down the amino acid L-lsyine and convert L-Dex into Dexamphetamine
- helping with my binge eating disorder, and will stop me using clembuterol and T3 to lose weight
- Had conversations with doctors online who've told me Wellbuterin and Vyvanse are two of the best drugs on the market for depression and ADHD and an excellent combination
- I spoken with many patients on the same combination with positive reviews
- Wellbuterin aids with weightloss, which will stop me taking PEDs, gaining weight and improve my self-esteem
- Wellbuterin is safe on sexual organs, which I have suffered with on SSRIs.
- Wellbuterin increases the effectivity of aripiprazole
- No anxiety or "come-up" like with many stimulants due to the gradual release.
- components of ADHD
1) dopamine related "attention-regulation".
2) Norepinephrine "procrastination/motivation" component.
- Vyvanse aids dopamine related attention regulation and bupropion aids Norepinephrine related procrastination.
- Bupropion aids in withdrawal from illicit substances such as alcohol and cigarettes, two things I'm trying to quit. It will also keep me from trying new substances.
- Risk of serotonin syndrome. Schizoprenics have high serotonin and this is what causes positive schizoprenic symptoms. Clonazepam reducing the utilisation 5-HT serotonin by neurons
- A previous doctor perscribed Sertraline (SSRI) which increases serotonin, this caused me to experience voices, hallucinations and other positive symptoms.
- Bupropion does not have any affect on serotonin
- Normally when I stand up quickly, I blackout but increased heart rate and blood pressure have prevented this
- Although Aripiprazole is a dopamine agonist and Vyvanse increases Dopamine in different receptor subtypes between neurons, they do so via different biological pathways.
- Aripiprazole is more of a dopamine optimiser, and manager than a pure agonist
- Stimulants are strongest at the D1 receptor, while anti-psychotics act on D2 antagonism. Although both medications act on all 5 receptors. Bupropions affect on dopamine are weak, and unlikely to interfere with the supply of dopamine by Vyvanse and then the optimisation of it by aripiprazole.
- Complex dopamine theory suggests that concurrent stimulant-antipsychotic use reduces tolerance and side effects
- Bupropion and aripiprazole combination have proven synergistic in the treatment compared to additional supplementation of an SSRI.
- Bupropion has shown to help improve cognition through mechanisms stimulants do not target
- Bupropion is the best anti-depressant to take with ADHD medications compared to SSRIs because it has no bearing on serotonin, which can cause serotonin syndrome.
- Clonazepam Inhibits neurotransmitter GABA, which reduces anxiety from Vyvanse comedown and will also aid sleep which is affected by stimulants
- Magnesium Threonate, Calcium Carbonate and TUMS can potentiate the effect of vyvanse.
