Suffering with depression as I have done in waves over the last 15 years. Currently it manifests as exhaustion, lack of motivation and a decreased ability to take pleasure in anything I used to enjoy. It's becoming intolerable. I'm on 150mg of Venlafaxine but don't want to be any longer, I'm suspicious that the blunting effect is contributing/causing the anehdonia. I ran out of these whilst on holiday in the summer and whilst there were a few unpleasant side effects, I could suddenly enjoy food, sex and music so much more. It was amazing for a time..until I started to feel a bit unhinged and like I was capable of headbutting my manager in a meeting if the thought merely crossed my mind. So back on the Vs I went..and the malaise is back. Doing some research makes me wonder if Bupropion would be a suitable drug to try..anyone have experience if it they could share? Also if you are UK based, who prescribed it for you? Cheers for sticking with this ramble..if you did!!