Pregabalin is a gabapentinoid like gabapentin.
Gabapentin can cause serotonin syndrome when used in combination with tramadol. Interestingly enough pregabalin has citations for causing serotonin syndrome as well. In fact, there's a citation where the combination of pregabalin and oxycodone instigated serotonin syndrome. Pregabalin is an analog of gabapentin and tramadol is a synthetic analog to oxycodone.
From personal use gabapentin taken beforehand does weird things with subjective effects. I think it may actually have a dampening effect like an SSRI for whatever reason. Gabapentin taken during the come down to balance the effects causes significant extension of after effects. Possibly do to serotonin because gabapentin raises serum serotonin.
I would hold off until the Lyrica is out of your system.
Thanks for the info and advice. Unfortunately, I'm a dumb-ass, and so I dosed.... whatever it is..... as soon as it got here. Of course, this was 2 days ago now. I didn't notice anything out of the ordinary, no negative effects from the mix. I had taken the Lyrica early that evening, and my guy only showed up around 3-4am. I doubt the Pregab had run its course completely, but at least there were several hours between them.
No, I didn't know that about Lyrica, that there could be a serotonin syndrome problem with it. Thanks for telling me, I'll keep it in mind.
Now Tramadol, I've never taken it, but from what I've read (here and elsewhere) I'm not sure I ever want to, tbh! Lol.... Seen some reports where people had some w.e.i.r.d. experiences and ended up in the psych-ward trying to gnaw their leg off or something? Yeesh.
Something interesting to note that I've been reflecting on lately is how the "buzz" of Gabapentin and Lyrica used to be for me like 14yrs ago, compared to today. I once had a prescription of 800mg 3x per day. Taking it as directed had no noticeable effect whatsoever, so I let it accumulate for months. At some point I had a huge stash, and I eventually learned how to get properly high on it.
I'd describe the effects back then as total-and-complete CNS depression/relief, it was truly amazing. I've seen how people here advise taking it, and despite what the literature says about metabolism rates, I found the best way (and only way, for me) was to take a huge amount at one time. First time I did it was 4000mg's in one shot. I knew it took 2hrs to kick in, so I put a movie on ("School of Rock" w/ Jack Black). Near the end of the film the effects started coming on, and it was glorious! I *literally* was crying and applauding the kids in the movie for the song they made ("They did it so well!") lolz. After that, I experimented with it heavily. I had zero trouble with tolerance, and often took it 3-5 days in a row with no lessening of effects from concurrent usage. To the contrary, I remember being very pleased that I had a drug that I could take days in a row with the buzz remaining the same. Most I ever took at once was 16,000mg
*Do Not Try This At Home Kids* .....I did NOT have a pleasant experience that night. Way too strong.
Around 2011 I tried Lyrica for the first time, and I probably took 500mg's but spaced out, like gradually redosing every hour or 30-45min, something like that. Man.... that was one of the highest times I'd ever been. I remember wondering if it would ever end, although it wasn't unpleasant, just intense. Same sort of CNS depressant, but with something else difficult to describe, comparable to the feeling in your head when you've smoked WAY too much weed.
Nowadays, the buzz on either is totally different. It's "glitchy." Both of them, Gaba and Pregab. It tends to make me a bit shaky or jittery, almost "speedy" but less "cracked-out"/anxious. I want to do things quick and pay less attention to detail, thus screwing up whatever I'm trying to do. The buzz is totally different, no CNS relief like back then. I'm somewhat disappointed, but hey.... it still has an effect.... except now I totally notice the tolerance thing. What a bummer (I realize in the UK "bummer" means something quite different lol).
Anyway, I don't know what happened, but my guess is that my "wiring" has gotten all messed up and fried from taking so many drugs over the years. My nervous system may be shot, I dunno. Sucks.
