Well... How long and dosage? I've been on it at 200-mg, likely 1/2 your dose nine years. It hasn't appeared to me to mute any drug, except maybe benzos. But that's not a bad thing unless you have a 5-mg/day clonazolam habit... However, it goes a long way towards seizure control and even withdrawal when I've tapered using diazepam.
For me lamotragine plays well with others, ime, very neutral.
Again, dose & how long you been on it?
This is not medical advice. Do not mix drugs that have no history of study behind them, don't be me: lamotragine, bupe, clonazolam, b.p. med, testosterone, Vyvanse - each prescribed. High grade weed. LSD, ETH-LAD,, bombers, MDMA. And... S.A. cocaine when I'm there. occasional alcohol... I want off all of them. Going to require years of tapers.....