Pharmacology Another kratom pharmacology question

[Juicewrldfan]

Based on this article, would you say that
7-OH is a better analgesic or mitrigynine psuedoindoxil?

I’m having a hard time determining this. It would seem the later is but then it looks like the previous tests 7-OH did better, but I have a limited understanding of these things.

Mitragyna speciosa: Balancing Potential Medical Benefits and Abuse

Mitragyna speciosa, also known as kratom, has the potential meet the need for pain medications that lack the addictiveness and overdose risk of classical opioid analgesics, such as morphine. This need is urgent because opioid addiction and overdose deaths ...

www.ncbi.nlm.nih.gov

 

[Snafu in the Void]

Pseudoindoxil is more potent than 7-OH, meaning less is required to produce an effect, however 7-OH scored higher on antinociceptive tests than both psuedoindoxil and morphine which suggests it is probably the more powerful analgesic compared to pseudoindoxil. More potent doesn't always mean better.

Of course, this is only rating how much mice react to induced pain or discomfort, which is indicative of analgesia but not necessarily how much a human would enjoy it. We can't ask mice about their subjective pain levels or how the drug made them feel.

That's my limited understanding at least.

 

[Didgital]

Pseudoindoxil is more potent than 7-OH, meaning less is required to produce an effect, however 7-OH scored higher on antinociceptive tests than both psuedoindoxil and morphine which suggests it is probably the more powerful analgesic compared to pseudoindoxil. More potent doesn't always mean better.

Of course, this is only rating how much mice react to induced pain or discomfort, which is indicative of analgesia but not necessarily how much a human would enjoy it. We can't ask mice about their subjective pain levels or how the drug made them feel.

That's my limited understanding at least.

My chemist friend somehow obtained both as isolates and says they are really nice.

Even regular mitragynine is very nice when pure.