Magnesium didn't work for me with d-amphetamine. What works for me is taking some kind of a sedative (alcohol or benzos work) shortly after the peak, or an opiate during the comedown; then the next day its like it never happened and I can take the same dose again and get the same results.
There is a large gray area between amphetamine "tolerance" and simply being burnt out. When your body wants to be done with the binge, it's done with the binge.. You could keep going of course, at the risk of going psychotic.
Taking chelated Mg can in principle do two things for amphet metabolism. First, it acts as a voltage-gated NMDA antagonist which, paradoxically, filters out the background noise from the stronger signals. Second, the anion with which the Mg has been chelated can effect excretion. Anions like malate, citrate, lactate and possibly tartrate have the effect of alkalinising the urine metabolically and therefore slowing down the elimination of amphet and many other substances. This is not quite the same as glugging down some antacid like NaHCO3, because all this will do is react with the stomach acid and perform neutralisation at that point. Metabolic alkalinisers have their effect further downstream (relying on liver breakdown) and are more effective at changing renal ph gradients, which is where most of the drug excretion occurs.
You
do not want a slower elimination with amphetamine. Do you realize how long amphetamine's half-life is? The reason it stops producing desired effects after a certain point is not because there is less of the drug in the system, but because the CNS is tapped.. You may have noticed that eating a meal or taking a small nap after you thought you already came down can cause it to kick right back in again.
What you actually want is a faster elimination; that way, a portion of your dose has actually left your system after, say, 6 hours, and taking more will actually make it kick back in again. I'd say when there's more than about 150mg in your system, taking more just doesn't really do anything positive -- if you actually want to binge, and you did something like take a proton pump inhibitor or swallowed a few tablespoons of baking soda or something else to totally mess with the drug's elimination, you'll end up accruing an amount in your system far larger than you think, and if you've got 200mg sitting in your system due to it building up from amph's obscene half-life and take another 30mg thinking its actually going to do anything, you're fooling yourself.
You want to aim for lower doses and faster eliminations... had about 5 years experience with this stuff and I swear by it.
I've also read that d-amph doses of 100mg+ cross a threshold where it acts as a DRI in addition to causing exocytosis of dopamine vesicles, and that's been consistent with my own experience. I always try to aim for that amount in my system - no more, no less. It really feels like reaching the next plateau, and is much more mellow and euphoric than what lower-end doses provide.
But seriously though, you don't want a longer elimination with amphetamine. It's already going to be romping you for 12 hours and you're going to be lucky if you can get to sleep at all no matter what time of the day you took it.
I recently found out about an upcoming work related 10-panel, so I've been off anything scheduled recently so as to not piss hot. (I am scripted trazodone, so if they don't follow up with GC/MS I theoretically could take amps and probably have the positive overlooked, but I don't want to risk it in case they do go GC/MS). Sodium butyrate testing delayed another week or two. At least it has served to prove I'm not addicted
On the other hand though, I recently found this rather shocking study:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701286/
"methylphenidate has the intriguing ability to provide neuroprotection from the neurotoxic effects of methamphetamine"
It's true; DRIs like cocaine, methylphenidate, and even ginseng have some kind of weird blocking effect against amphetamine and methamphetamine. But the peripheral effects still compound with each other, which leads to a really horrible experience. So although methylphenidate might provide neuroprotection, its not worth the agonizing pain your entire body will be in for 5 days afterwards.
